Anti-IL-6R Antibody

Cat: 10398-MM08
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All IL-6R Reagents
Anti-IL-6R Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IL-6R Antibody
Validated applications
Species reactivity
Reacts with: Human
Human IL-6R
No cross-reactivity with rat IL6R (Catalog # 81072-R02H) , mouse IL6R (Catalog # 50280-M08H) and canine IL6R (Catalog # 70117-D08H) in ELISA assay
Recombinant Human IL-6R / CD126 protein (Catalog#10398-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; Catalog#10398-H08H; NP_000556.1; Met1-Pro365). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #3H7D3H1
Protein A
0.2 μm filtered solution in PBS
Please contact us for more information.
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-6R Antibody (Mouse Monoclonal antibody) Validated Applications
Application Notes
Block This IL6R Neutralizing Antibody can not block the binding of recombinant IL6 (Catalog # 10395-HNAE) to its recombinant receptor IL6 Rα (Catalog # 10398-H08H) .
Neutralization The neutralization activity of IL6R Neutralizing Antibody is measured by its ability to neutralize IL6 Rα-mediated inhibition of proliferation in the M1 mouse myeloid leukemia cell line. The Neutralization Titer (IC50) is typically 0.15-0.6 µg/mL in the presence of 50 ng/mL Recombinant Human IL6 Rα (Catalog # 10398-H08H) and 100 ng/mL Recombinant Human IL6 (Catalog # 10395-HNAE) .

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-6R Antibody (Mouse Monoclonal antibody) Images
Human IL6R/IL-6R/CD126 Blocking/Neutralization (B/N) 5577
IL-6 Rα Enhancement of IL6-dependent Inhibition of Cell Proliferation was Neutralized by Human IL-6 Rα Neutralizing Antibody in the M1 mouse myeloid leukemia cell line. Enhancement of Recombinant Human IL6 (100 ng/mL) activity elicited by Recombinant Human IL-6 Rα (50 ng/mL) is neutralized by increasing concentrations of Human IL6 Rα neutralizing Monoclonal Antibody (Catalog # 10398-MM08H). The IC50 is typically 0.15-0.6 μg/mL.
Anti-IL-6R Antibody Alternative Names
Anti-CD126 Antibody;Anti-gp80 Antibody;Anti-IL-6R Antibody;Anti-IL-6R-1 Antibody;Anti-IL-6RA Antibody;Anti-IL6Q Antibody;Anti-IL6RA Antibody;Anti-IL6RQ Antibody
IL-6R Background Information

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 6 receptor
  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-6R Antibody Rabbit Polyclonal WB,ELISA 81072-T48
    Anti-IL-6R Antibody (APC) Rabbit Monoclonal FCM 50280-R033-A
    Anti-IL-6R Antibody (PE) Rabbit Monoclonal FCM 50280-R033-P
    Anti-IL-6R Antibody Rabbit Monoclonal ELISA(Cap),FCM,ICC/IF,IF 50280-R033
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 50280-RP01
    Anti-IL-6R Antibody Rabbit Polyclonal WB,ELISA 50280-RP02
    Anti-IL-6R Antibody Rabbit Monoclonal ELISA 50280-R005
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-RP02
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-RP03
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-RP01
    Anti-IL-6R Antibody Mouse Monoclonal ELISA 10398-MM01
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-T16
    Anti-IL-6R Antibody Mouse Monoclonal ELISA(Cap),ICC/IF,IF 10398-MM18
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