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IL6R/IL-6R/CD126 Rabbit PAb , Antigen Affinity Purified

  • IL6RA / CD126 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Mouse IL6R Antibody Product Information
Immunogen:Recombinant Mouse IL6RA protein (Catalog#50280-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Mouse IL6RA / CD126 (rM IL6RA; Catalog#50280-M08H; NP_034689.2; Ile 44-Glu 357). IL6RA specific IgG was purified by mouse IL6RA affinity chromatography.
Mouse IL6R Antibody WB Application Image
Other IL6R Antibody Products
Reactivity: Human  
Application: B/N  
  • Slide 1
10398-MM08-500
10398-MM08-200
500 µg 
200 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10398-MM01-50
    10398-MM01-100
    10398-MM01-200
    50 µg 
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10398-RP02-400
      10398-RP02-100
      10398-RP02-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10398-RP03-200
        10398-RP03-50
        10398-RP03-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: IF  ICC/IF  
        • Slide 1
        10398-MM18-200
        10398-MM18-100
        10398-MM18-50
        200 µg 
        100 µg 
        50 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10398-T16-200
          10398-T16-50
          10398-T16-100
          200 µg 
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10398-RP01-400
            10398-RP01-200
            10398-RP01-100
             
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50280-RP01-100
              50280-RP01-200
              50280-RP01-400
              100 µg 
              200 µg 
               
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50280-R005-50
                50280-R005-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: FCM  
                • Slide 1
                50280-R033-P-100
                50280-R033-P-50
                100 Tests 
                50 Tests 
                Add to Cart
                Reactivity: Mouse  
                Application: FCM  
                • Slide 1
                50280-R033-A-100
                50280-R033-A-50
                100 Tests 
                50 Tests 
                Add to Cart
                Reactivity: Mouse  
                Application: FCM  IF  ICC/IF  
                • Slide 1
                • Slide 1
                50280-R033-100
                50280-R033-50
                100 µg 
                50 µg 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  WB  
                • Slide 1
                81072-T48-50
                81072-T48-100
                81072-T48-200
                50 µg 
                100 µg 
                200 µg 
                Add to Cart
                IL6R/IL-6R/CD126 Background

                Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                Mouse IL6R/IL-6R/CD126 References
              • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
              • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
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                Catalog: 50280-RP02-50
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"