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IL6R / CD126 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human IL6R Antibody Product Information
Immunogen:Recombinant Human IL6R protein (Catalog#10398-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human IL6 receptor extracellular domain (rhIL6R; Catalog#10398-H08H; NP_000556.1; Met 1-Pro 365). IL6R specific IgG was purified by human IL6R affinity chromatography.
Human IL6R Antibody Usage Guide
Specificity:Human IL6R / CD126
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human IL6R. The detection limit for Human IL6R is 0.0049 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IL6R Antibody Products
Reactivity: Human  
Application: B/N  
  • Slide 1
10398-MM08-500
10398-MM08-200
500 µg 
200 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10398-MM01-50
    10398-MM01-100
    10398-MM01-200
    50 µg 
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10398-RP02-400
      10398-RP02-100
      10398-RP02-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: IF  ICC/IF  
      • Slide 1
      10398-MM18-200
      10398-MM18-100
      10398-MM18-50
      200 µg 
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10398-T16-200
        10398-T16-50
        10398-T16-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10398-RP01-400
          10398-RP01-200
          10398-RP01-100
           
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50280-RP01-100
            50280-RP01-200
            50280-RP01-400
            100 µg 
            200 µg 
             
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  WB  
            • Slide 1
            50280-RP02-50
            50280-RP02-100
            50280-RP02-200
            50 µg 
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50280-R005-50
              50280-R005-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: FCM  
              • Slide 1
              50280-R033-P-100
              50280-R033-P-50
              100 Tests 
              50 Tests 
              Add to Cart
              Reactivity: Mouse  
              Application: FCM  
              • Slide 1
              50280-R033-A-100
              50280-R033-A-50
              100 Tests 
              50 Tests 
              Add to Cart
              Reactivity: Mouse  
              Application: FCM  IF  ICC/IF  
              • Slide 1
              • Slide 1
              50280-R033-100
              50280-R033-50
              100 µg 
              50 µg 
              Add to Cart
              Reactivity: Rat  
              Application: ELISA  WB  
              • Slide 1
              81072-T48-50
              81072-T48-100
              81072-T48-200
              50 µg 
              100 µg 
              200 µg 
              Add to Cart
              IL6R/IL-6R/CD126 Background

              Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

              Human IL6R/IL-6R/CD126 References
            • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
            • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
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              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"