Anti-IL-6R Antibody (FITC)

Cat: 10398-MM20-F
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Anti-IL-6R Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-IL-6R Antibody (FITC)
Validated applications
Species reactivity
Reacts with: Human
Human IL-6R
Recombinant Human IL-6R / CD126 protein (Catalog#10398-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; Catalog#10398-H08H; NP_000556.1; Met 1-Pro 365) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Monoclonal Mouse IgG1 Clone #20
Protein A
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
5 μl/Test, 0.2 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-IL-6R Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-6R Antibody (FITC) (Mouse Monoclonal antibody) Images
Human IL6R/IL-6R/CD126 Flow Cytometry (FC) 5392
Flow cytometric analysis of anti-human IL6R (CD126) on Jurkat cells.
Anti-IL-6R Antibody (FITC) Alternative Names
Anti-CD126 Antibody;Anti-gp80 Antibody;Anti-IL-6R Antibody;Anti-IL-6R-1 Antibody;Anti-IL-6RA Antibody;Anti-IL6Q Antibody;Anti-IL6RA Antibody;Anti-IL6RQ Antibody
IL-6R Background Information

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 6 receptor
  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-IL-6R Antibody Rabbit Monoclonal ELISA 50280-R005
    Anti-IL-6R Antibody Rabbit Monoclonal ELISA(Cap),FCM,ICC/IF,IF 50280-R033
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 50280-RP01
    Anti-IL-6R Antibody Rabbit Polyclonal WB,ELISA 50280-RP02
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-RP02
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-RP03
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-RP01
    Anti-IL-6R Antibody Mouse Monoclonal ELISA 10398-MM01
    Anti-IL-6R Antibody Rabbit Polyclonal ELISA 10398-T16
    Anti-IL-6R Antibody Mouse Monoclonal Neutralization 10398-MM08
    Anti-IL-6R Antibody Mouse Monoclonal ELISA(Cap),ICC/IF,IF 10398-MM18
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