IL-6 Protein & Antibody (BSF2)

Interleukin-6 (B cell stimulatory factor-2)

IL-6 Protein & Antibody

Sino Biological offers a comprehensive set of research tools for research on interleukin-6 family ligands and receptors. These include recombinant proteins, monoclonal/polyclonal antibodies and ORF cDNA Clones. Our antibody products include mouse monoclonal and rabbit polyclonal antibodies for application such as ELISA, Western Blotting, IHC, etc. All of our antibodies were generated with recombinant full length protein as immunogen, which ensures better binding affinity and specificity to the native protein.

IL-6 Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-6	Human	IL-6 Protein, Recombinant	10395-HNAE

  10395-HNAE:  Immobilized recombinant human IL-6 at 8 μg/mL (100μl/well) can bind recombinant human IL6R with a linear range of 1.25 - 20.0 ng/ml. Measured by its binding ability in a functional ELISA.

IL-6 Antibody

Molecule	Application	Description	Cat. No
Human IL-6	ELISA	Mouse Monoclonal Antibody	10395-MM02
Human IL-6	ELISA	Rabbit Polyclonal Antibody	10395-RP01
Human IL-6	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10395-RP03
Human IL-6	WB, ELISA	IL-6 Antibody	10395-R057

IL-6 ELISA Kit

Molecule	Application	Description	Cat. No
Human IL-6	ELISA	IL-6 ELISA Kit	SEK10395

IL-6 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-6

Cancer>>Cancer Biomarkers>>IL-6

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-6 Family & Receptor>>IL-6

IL-6 Alternative Names

IL-6, IL6, BSF2, HGF, HSF, IFNB2

IL-6 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Leptin	Human	Leptin Protein, Recombinant
Leptin Receptor/CD295	Human	Leptin Receptor/CD295/Fc Protein, Recombinant
IL-6R/CD126	Human	IL-6R/CD126 Protein, Recombinant
IL-6R/CD126	Mouse	IL-6R/CD126 Protein, Recombinant
gp130/IL6ST/CD130	Human	gp130/IL6ST/CD130/Fc Protein, Recombinant
gp130/IL6ST/CD130	Mouse	gp130/IL6ST/CD130 Protein, Recombinant
LIFR/CD118	Human	LIFR/CD118 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human IL-6R/CD126	ELISA	Mouse Monoclonal Antibody
Human IL-6R/CD126	ELISA	Rabbit Polyclonal Antibody
Human IL-6R/CD126	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse IL-6R/CD126	WB, ELISA	Rabbit Polyclonal Antibody
Mouse IL-6R/CD126	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
CLC/CLCF1	Human	Homo sapiens CLC/CLCF1 cDNA Clone(NM_013246.2)
Leptin	Human	Homo sapiens Leptin cDNA Clone(NM_000230.2)
Leptin Receptor/CD295	Human	Homo sapiens Leptin Receptor/CD295 transcript variant 1 cDNA Clone(NM_002303.3)
IL-6	Human	Homo sapiens IL-6 cDNA Clone(NM_000600.2)
IL-6R/CD126	Human	Homo sapiens IL-6R/CD126 transcript variant 1 cDNA Clone(NM_000565.2)
IL-11Ra	Human	Homo sapiens IL-11Ra transcript variant 1 cDNA Clone(NM_004512.3)
Oncostatin M/OSM	Human	Homo sapiens Oncostatin M/OSM

IL-6 Background

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

IL-6 Related Studies

1. Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1–20.
2. Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
3. Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.