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IL6/IL-6/Interleukin-6 Rabbit MAb

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    Human IL6 Antibody Product Information
    Immunogen:Recombinant Human IL-6 Protein (Catalog#10395-HNAE)
    Clone ID:057
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-6 (rh IL-6; Catalog#10395-HNAE; Val 30-Met 212; NP_000591.1).
    Other IL6 Antibody Products
    Reactivity: Human  
    Application: B/N  
    • Slide 1
    10395-mhK23-200
    10395-mhK23-500
    200 µg 
    500 µg 
    Add to Cart
    Reactivity: Human  
    Application: B/N  
    • Slide 1
    10395-R508-200
    10395-R508-500
    200 µg 
    500 µg 
    Add to Cart
    Reactivity: Human  
    Application: IHC-P  
    • Slide 1
    • Slide 1
    10395-MM10-100
    10395-MM10-50
    10395-MM10-200
    100 µg 
    50 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IP  
    • Slide 1
    • Slide 1
    10395-T52-50
    10395-T52-100
    10395-T52-200
    50 µg 
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  
    • Slide 1
    10395-T48-100
    10395-T48-50
    10395-T48-200
    100 µg 
    50 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10395-RP01-100
      10395-RP01-200
      10395-RP01-400
      100 µg 
      200 µg 
       
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10395-MM02-50
        10395-MM02-100
        10395-MM02-200
        50 µg 
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  WB  
        • Slide 1
        10395-RP03-100
        10395-RP03-50
        10395-RP03-200
        100 µg 
        50 µg 
        200 µg 
        Add to Cart
        Reactivity: Human  
        Application: B/N  
          10395-MK23-200
          10395-MK23-500
          200 µg 
          500 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10395-T16-100
            10395-T16-50
            10395-T16-200
            100 µg 
            50 µg 
            200 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  WB  
            • Slide 1
            50136-T48-200
            50136-T48-50
            50136-T48-100
            200 µg 
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50136-RP01-400
              50136-RP01-200
              50136-RP01-100
               
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Rat  
              Application: ELISA  
                80076-R007-50
                80076-R007-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80076-T16-50
                  80076-T16-200
                  80076-T16-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Cynomolgus  
                  Application: ELISA  IHC-P  
                  • Slide 1
                  • Slide 1
                  • Slide 1
                  • Slide 1
                  • Slide 1
                  90197-RP02-50
                  90197-RP02-100
                  90197-RP02-200
                  50 µg 
                  100 µg 
                  200 µg 
                  Add to Cart
                  Reactivity: Rhesus  
                  Application: ELISA  
                    90197-RP01-200
                    90197-RP01-100
                    90197-RP01-400
                    200 µg 
                    100 µg 
                     
                    Add to Cart
                    Reactivity: Sus scrofa (Pig)  
                    Application: ELISA  
                      62006-RP01-100
                      62006-RP01-400
                      62006-RP01-200
                      100 µg 
                       
                      200 µg 
                      Add to Cart
                      Reactivity: Sus scrofa (Pig)  
                      Application: ELISA  
                        62006-T16-200
                        62006-T16-100
                        62006-T16-50
                        200 µg 
                        100 µg 
                        50 µg 
                        Add to Cart
                        IL6/IL-6/Interleukin-6 Background

                        Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

                        Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                        Human IL6/IL-6/Interleukin-6 References
                      • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
                      • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
                      • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.
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                        Catalog: 10395-R057-1
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                        Datasheet & Documentation

                        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"