Anti-IL-6 Antibody

Cat: 10395-RP01
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All IL-6 Reagents
Anti-IL-6 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL-6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL-6
Immunogen
Recombinant Human IL6 protein (Catalog#10395-HNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL6. Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-6 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-6 Antibody Alternative Names
Anti-BSF2 Antibody;Anti-HGF Antibody;Anti-HSF Antibody;Anti-IFNB2 Antibody;Anti-IL-6 Antibody;Anti-Interleukin-6 Antibody
IL-6 Background Information

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 6
References
  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-IL-6 Antibody Mouse Monoclonal Neutralization 10395-mhK23
    Anti-IL-6 Antibody Mouse Monoclonal IHC-P 10395-MM10
    Anti-IL-6 Antibody Rabbit Monoclonal Neutralization 10395-R508
    Anti-IL-6 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10395-MM14
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