IL-4R Protein & Antibody (CD124)

Interleukin 4 Receptor (Cluster of Differentiation 124)

IL-4R / CD124 Products

IL-4R Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-4R/CD124	Human	IL-4R/CD124 Protein, Recombinant	10402-H08H
IL-4R/CD124	Rat	IL4R / Il4ra Protein, Recombinant	80198-R08H

IL-4R Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-4R/CD124	ELISA	Mouse Monoclonal Antibody	10402-MM01
Human IL-4R/CD124	WB	Mouse Monoclonal Antibody	10402-MM11
Human IL-4R/CD124	WB, ELISA	Rabbit Monoclonal Antibody	10402-R102
Human IL-4R/CD124	WB, ELISA	Rabbit Polyclonal Antibody	10402-RP01
Human IL-4R/CD124	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10402-RP02

IL-4R ELISA Kits

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-4R/CD124	ELISA	IL4R / CD124 ELISA Pair Set, Human ELISA Pair Set	SEK10402

IL-4R cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-4R/CD124	Human	Homo sapiens IL-4R/CD124 transcript variant 1 cDNA Clone(NM_000418.2)	HG10402-M
IL-4R/CD124	Rat	Rat IL-4R/CD124 transcript variant 1 cDNA Clone	RG80198-G

IL-4R / CD124 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-4R/CD124

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-4R/CD124

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> IL-4R/CD124

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL-4R/CD124

IL-4R / CD124 Alternative Names

IL4R, CD124, IL4RA [Homo sapiens]

Il4r, CD124, Il4ra, MGC118473 [Mus musculus]

IL-4R / CD124 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.

IL-4R / CD124 Related Studies

Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.