Anti-IL-4 Antibody

Cat: 11846-R101
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All IL-4 Reagents
Anti-IL-4 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-IL-4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL-4
No cross-reactivity in ELISA with Mouse IL4 Canine IL4
Immunogen
Recombinant Human IL-4 / IL4 / Interleukin-4 protein (Catalog#11846-HNAE)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-4 / IL4 / Interleukin-4 (rh IL-4 / IL4 / Interleukin-4; Catalog#11846-HNAE; P05112-1; His25-Ser153).
Source
Monoclonal Rabbit IgG Clone #101
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-4 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-4 Antibody Alternative Names
Anti-BCGF-1 Antibody;Anti-BCGF1 Antibody;Anti-BSF-1 Antibody;Anti-BSF1 Antibody;Anti-IL-4 Antibody;Anti-Interleukin-4 Antibody
IL-4 Background Information

Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and for the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as of other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibites in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and of the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 4
References
  • Grunewald SM. et al., 1998, J Immunol. 160 (8): 4004-9.
  • Susanne M. et al, 1997, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 272 (3): 1480-3.
  • Nishikubo K. et al., 2003, Gene Ther. 10 (26): 2119-25.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-4 Antibody Rabbit Polyclonal ELISA 70021-RP01
    Anti-IL-4 Antibody Rabbit Monoclonal ELISA 51084-R015
    Anti-IL-4 Antibody Rabbit Polyclonal WB 51084-T32
    Anti-IL-4 Antibody Rabbit Polyclonal ELISA 51084-RP01
    Anti-IL-4 Antibody Mouse Monoclonal ELISA(Cap) 11846-MM05
    Anti-IL-4 Antibody Mouse Monoclonal ELISA(Det) 11846-MM04
    Anti-IL-4 Antibody Rabbit Monoclonal WB 11846-R404
    Anti-IL-4 Antibody Rabbit Polyclonal ELISA 11846-RP01
    Anti-IL-4 Antibody Rabbit Polyclonal ELISA 11846-T16
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