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IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified

  • IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Mouse IL36B Antibody Product Information
Immunogen:Recombinant Mouse IL-36B / IL-1F8 protein (Catalog#51071-MNAE)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Mouse IL-36B / IL-1F8 (rM IL-36B / IL-1F8; Catalog#51071-MNAE; Q9D6Z6; Met1-Lys183). IL-36B / IL-1F8 specific IgG was purified by Mouse IL-36B / IL-1F8 affinity chromatography.
Mouse IL36B Antibody WB Application Image
Mouse IL36B Antibody IHC Application Image
IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse IL1F8 in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse IL1F8 in mouse stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other IL36B Antibody Products
IL36B/IL1F8 Background

Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.

Mouse IL36B/IL1F8 References
  • Magne D, et al. (2006) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Research & Therapy. 8: R80.
  • Smith DE, et al. (2000) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. The Journal of Biological Chemistry. 275: 1169-75.
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