All IL-32 reagents are produced in house and quality controlled, including 8 IL-32 Antibody, 2 IL-32 ELISA, 12 IL-32 Gene, 1 IL-32 IPKit, 1 IL-32 Lysate, 1 IL-32 Protein, 1 IL-32 qPCR. All IL-32 reagents are ready to use.
Recombinant IL-32 proteins are expressed by HEK293 Cells with fusion tags as C-His.
IL-32antibodies are validated with different applications, which are ELISA, WB, ELISA(Cap), IP, ELISA(Det).
IL-32cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL-32 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL-32ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and in human stomach cancer, human lung cancer and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.