IL-32 alpha Protein & Antibody

 Interleukin-32 alpha

IL-32 alpha Products

IL-32 alpha Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-32 alpha	Human	IL-32 alpha Protein, Recombinant	11064-H08H

IL-32 alpha Antibody

Molecule	Application	Description	Cat. No
Human IL-32 alpha	ELISA	IL-32 alpha Antibody, Rabbit Mab	11064-R030
Human IL-32 alpha	ELISA	Rabbit Polyclonal Antibody	11064-RP01

IL-32 alpha Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>IL-32 alpha

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-32 alpha

IL-32 alpha Alternative Names

IL-32 alpha, IL-32beta, IL-32delta, IL-32gamma, IL32, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd

IL-32 Background

IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and in human stomach cancer, human lung cancer and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

IL-32 Related Studies

1. Felaco P, et al. (2009) IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents. 23(3): 141-7.
2. Kobayashi H, et al. (2009) Molecular characterization of IL-32 in human endothelial cells. Cytokine. 46(3): 351-8.
3. Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125(4): 858-865.