IL-32 (Protein | Antibody | cDNA Clone | ELISA Kit)

All IL-32 reagents are produced in house and quality controlled, including 8 IL-32 Antibody, 2 IL-32 ELISA, 13 IL-32 Gene, 1 IL-32 Lysate, 1 IL-32 Protein, 1 IL-32 qPCR. All IL-32 reagents are ready to use.

IL-32 Protein (1)

IL-32 Antibody (8)

IL-32 ELISA Kit & Match Antibody ELISA Pair Set (2)

IL-32 cDNA Clone (13)

NM_004221.4

IL-32 qPCR Primer (1)

IL-32 Lysate (1)

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IL-32 Background

IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and in human stomach cancer, human lung cancer and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

IL-32 References

  • Felaco P, et al. (2009) IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents. 23(3): 141-7.
  • Kobayashi H, et al. (2009) Molecular characterization of IL-32 in human endothelial cells. Cytokine. 46(3): 351-8.
  • Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125(4): 858-865.