Anti-IL-32 Antibody

Cat: 11064-R030
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Anti-IL-32 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-IL-32 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL-32
Immunogen
Recombinant Human IL-32 protein (Catalog#11064-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human interleukin-32 / IL-32 (rh IL-32; Catalog#11064-H08H; Met 1-Lys 131; NP_777596.2).
Source
Monoclonal Rabbit IgG Clone #030
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-32 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-32 Antibody Alternative Names
Anti-IL-32alpha Antibody;Anti-IL-32beta Antibody;Anti-IL-32delta Antibody;Anti-IL-32gamma Antibody;Anti-IL32 Antibody;Anti-NK4 Antibody;Anti-TAIF Antibody;Anti-TAIFa Antibody;Anti-TAIFb Antibody;Anti-TAIFc Antibody;Anti-TAIFd Antibody
IL-32 Background Information

IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and in human stomach cancer, human lung cancer and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

Full Name
interleukin 32
References
  • Felaco P, et al. (2009) IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents. 23(3): 141-7.
  • Kobayashi H, et al. (2009) Molecular characterization of IL-32 in human endothelial cells. Cytokine. 46(3): 351-8.
  • Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125(4): 858-865.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-32 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 11064-R403
    Anti-IL-32 Antibody Mouse Monoclonal WB 11064-MM12
    Anti-IL-32 Antibody Rabbit Polyclonal ELISA 11064-T16
    Anti-IL-32 Antibody Rabbit Polyclonal WB 100285-T32
    Anti-IL-32 Antibody Rabbit Monoclonal ELISA(Cap) 11064-R034
    Anti-IL-32 Antibody Rabbit Polyclonal ELISA 11064-RP01
    Anti-IL-32 Antibody Rabbit Polyclonal WB,ELISA 11064-T48
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