IL-3 Protein

Interleukin 3

IL-3 Products

IL-3 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-3/IL3	Human	IL-3/Interleukin-3 Protein, Recombinant	11858-H08B
IL-3/IL3	Rat	IL3 / interleukin 3 Protein, Recombinant	80235-R08B

  11858-H08B: The ED₅₀ for this effect is typically 0.5-1 ng/ml. Measured in a cell proliferation assay using TF1 human erythroleukemic cells. (Kitamura, T. et al. 1989 J. Cell Physiol. 140: 323.).

  10806-H02H:

1. The ED₅₀ for this effect is typically 0.5-1 ng/ml. Measured in a cell proliferation assay using TF1 human erythroleukemic cells. (Kitamura, T. et al. 1989 J. Cell Physiol. 140: 323.).

2. Immobilized human IL3 at 20 µg/ml (100 µl/well) can bind human IL3Ra with a linear ranger of 0.064-1.6 µg/ml. Immobilized human IL3 at 20 µg/ml (100 µl/well) can bind biotinylated human IL3Ra with a linear ranger of 0.32-1.6 µg/ml. Measured by its binding ability in a functional ELISA.

IL-3 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-3/IL3

IL-3 Alternative Names

IL-3, IL3, MCGF, MGC79398, MGC79399, MULTI-CSF [Homo sapiens]

IL-3, Il3, RP23-309E16.5, BPA, Csfmu, HCGF, Il-3, MCGF, PSF [Mus musculus]

IL3 / IL-3 Background

IL3 (interleukin 3), also known as IL-3, is a potent growth promoting cytokine which belongs to the IL-3 family. IL3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

IL3 / IL-3 Related Studies

1. Meyer CG, et al.. (2011) IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. Hum Mol Genet. 20(6):1173-81.
2. Zambrano A, et al. (2010) IL-3 controls tau modifications and protects cortical neurons from neurodegeneration. Curr Alzheimer Res. 7(7):615-24.
3. Dentelli P, et al.. (2011) IL-3 is a novel target to interfere with tumor vasculature. Oncogene. 30(50):4930-40.