IL-29 (Protein | Antibody | cDNA Clone | ELISA Kit)

All IL-29 reagents are produced in house and quality controlled, including 6 IL-29 Antibody, 2 IL-29 ELISA, 8 IL-29 Gene, 2 IL-29 Lysate, 2 IL-29 Protein, 1 IL-29 qPCR. All IL-29 reagents are ready to use.

IL-29 Protein (2)

IL-29 Antibody (6)

IL-29 ELISA Kit & Match Antibody ELISA Pair Set (2)

IL-29 cDNA Clone (8)

NM_172140.1

In lentiviral vector

IL-29 qPCR Primer (1)

IL-29 Lysate (2)

IL-29 Background

Interleukin-29(IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein which belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-1 receptor beta (IL-1Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL1RB and IL28RA. The ligand / receptor complex seems to signal through the Jak-STAT pathway.

IL-29 References

  • Li MC, et al. (2006) Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. Acta Pharmacol Sin. 27(4): 453-9.
  • Wang J, et al. (2009) Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. J Immunol. 182(3): 1296-304.
  • Jordan WJ, et al. (2007) Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29). Genes Immun. 8(1): 13-20.