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> IL-27 Protein IL-27 Protein
Interleukin 27
IL-27 Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-27 | Human | IL-27 Protein, Recombinant |
10076-H08H |
IL-27 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-27 | Rat | IL-27 cDNA Clone | RG80201-G |
All IL-27 Protein and Antibody
IL-27 Related Areas
Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-27
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>IL-27
IL-27 Alternative Names
IL-27, p28, IL27, IL-27A, IL27p28, EBI3, IL-27B, IL30, MGC71873 [Homo sapiens]
IL-27, p28, Il27, IL-27p28, Ebi3, EBI-3, Il30 [Mus musculus]
IL-27 Protein Related Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| IL-27Ra | Human | IL-27Rα/Fc Protein, Recombinant |
| IL12A/P35 | Human | IL-12A/P35/Fc Protein, Recombinant |
| IL12A/P35 | Human | IL12A/P35 Protein, Recombinant |
| IL12B/P40 | Human | IL-12B/P40/Fc Protein, Recombinant |
| IL12B/P40 | Human | IL-12B/P40 Protein, Recombinant |
| IL-35 | Human | Human IL-35/Fc Protein, Recombinant |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! |
| Human IL-12A/IL-12p35 |
WB, ELISA | IL-12A/IL-12p35 Antibody, Rabbit PAb |
| Human IL-12A/IL-12p35 |
WB, ELISA | IL-12A/IL-12p35 Antibody, Rabbit PAb (Antigen Affinity Purified) |
| Human IL12B/IL-12p40 |
ELISA | Mouse Monoclonal Antibody |
| Human IL-12B/IL-12p40 |
WB, ELISA | Rabbit Monoclonal Antibody |
| Human IL-12B/IL-12p40 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) |
| Human IL-12B/IL-12p40 |
WB, ELISA | Rabbit Polyclonal Antibody |
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| IL-27 | Human | Homo sapiens interleukin 27 cDNA Clone(NM_145659.3) |
| IL-27b | Human | Homo sapiens IL-27b cDNA Clone(NM_005755.2) |
| IL-27Ra | Human | Homo sapiens IL-27Ra cDNA Clone(NM_004843.2) |
| IL12A/P35 | Human | Homo sapiens interleukin 12A cDNA Clone(NM_000882.2) |
| IL12B/P40 | Human | Homo sapiens IL-12B/P40 cDNA Clone(NM_002187.2) |
| IL12Rb2 | Human | Homo sapiens IL-12Rb2 cDNA Clone(NM_001559.2) |
IL-27 Background
IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells and dendritic cells. IL-27 protein is also referred as the IL-12 p35-related protein, p28, is one subunit of a heterodimeric cytokine complex, and associates with another subunit EBI3 (EBV-induced gene 3), an IL-12 p40-related protein (IL-27B). IL-27 protein is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive CD4(+) T cells and plays a role in the early regulation of Th1 cells initiation which drives efficient adaptive immune response. IL-27 protein has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 protein may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy.
IL-27 Related Studies
- Hisada M, et al. (2004) Potent antitumor activity of interleukin-27. Cancer Res. 64(3): 1152-6.
- Larousserie F, et al. (2005) Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells. Am J Pathol. 166(4): 1217-28.
- Seita J, et al. (2008) Interleukin-27 directly induces differentiation in hematopoietic stem cells. Blood. 111(4): 1903-12.
