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> IL-25 Protein & Antibody (IL-17E) IL-25 Protein & Antibody (IL-17E)
Interleukin-25 (Interleukin-17E)
IL-25 Products
IL-25 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-25/IL-17E | Human | IL-25/IL-17E/Fc Protein, Recombinant |
10096-H01H |
| IL-25/IL-17E | Mouse | IL-25/IL-17E Protein, Recombinant | 50138-M07H |
10096-H01H: Measure by its ability to bind with recombinant human IL17BR in a functional ELISA.
IL-25 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Mouse IL-25/IL-17E |
WB, ELISA | Rabbit Polyclonal Antibody | 50138-RP01 |
| Mouse IL-25/IL-17E |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 50138-RP02 |
IL-25 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-25/IL-17E | Mouse | Mus musculus IL25/IL17E cDNA Clone | MG50138-M |
| IL-25/IL-17E | Rat | Rat IL25/IL17E cDNA Clone | RG80194-G |
IL-25 Related Areas
Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-25/IL-17E
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-17 Family & IL-17 Receptor Family>>IL-25/IL-17E
IL-25 Alternative Names
UNQ3120, PRO10272, IL17E [Homo sapiens]
IL-17e, Il17e [Mus musculus]
RGD1561632 [Rattus norvegicus]
IL-25 Background
Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.
IL-25 Related Studies
- Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
- Tamachi T, et al.. (2006) IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol. 118(3): 606-14.
- Kleinschek MA, et al.. (2007) IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med. 204(1): 161-70.