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Product Catalog
> IL-24 / MDA-7 Protein IL-24 / MDA-7 Protein
Interleukin 24 / Melanoma differentiation association protein 7
IL-24 / MDA-7 Products
IL-24 / MDA-7 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-24/MDA-7 | Human | IL-24/MDA-7 Protein, Recombinant | 12265-H08H |
IL-24 / MDA-7 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-24/MDA-7 | Human | IL24 cDNA Clone / ORF Clone | HG12265-G |
| IL-24/MDA-7 | Mouse | IL-24/MDA-7 cDNA Clone | MG51067-G |
IL-24 / MDA-7 Related Areas
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IL-24/MDA-7
IL-24 / MDA-7 Alternative Names
IL-24, MDA-7, IL24, C49A, FISP, IL10B, MDA7, MOB5, ST16 [Homo sapiens]
IL-24, MDA-7, Il24, FISP, Mda-7, Mda7, St16 [Mus musculus]
IL-24 / MDA-7 Background
Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7 can induce apoptosis selectively in various cancer cells. Overexpression of IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Human IL-24/MDA-7 is secreted by activated peripheral blood mononuclear cells and is the ligand for two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. Northern blot analysis revealed IL-24/MDA-7 expression in human tissues associated with the immune system such as spleen, thymus, peripheral blood leukocytes and normal melanocytes. IL-24 binding to either its endogenous receptors on human keratinocytes or to ectopically expressed receptors on baby hamster kidney cells leads to activation of the signal transducers and activators of transcription.
IL-24 / MDA-7 Related Studies
- Wang M, et al.. (2002) Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. J Biol Chem. 277(9): 7341-7.
- Sauane M, et al.. (2003) MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine Growth Factor Rev. 14(1): 35-51.
- Sarkar D, et al.. (2002) mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci U S A. 99(15): 10054-9.