All IL22RA1 reagents are produced in house and quality controlled, including 36 IL22RA1 Gene, 4 IL22RA1 Lysate, 4 IL22RA1 Protein, 2 IL22RA1 qPCR. All IL22RA1 reagents are ready to use.
Recombinant IL22RA1 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
IL22RA1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL22RA1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.