All IL21 Receptor reagents are produced in house and quality controlled, including 11 IL21 Receptor Antibody, 12 IL21 Receptor Gene, 7 IL21 Receptor Lysate, 7 IL21 Receptor Protein, 2 IL21 Receptor qPCR. All IL21 Receptor reagents are ready to use.
Recombinant IL21 Receptor proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc, C-mouse IgG1-Fc.
IL21 Receptorantibodies are validated with different applications, which are ELISA, IHC-P.
IL21 ReceptorcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL21 Receptor of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.