IL-21R Protein & Antibody

Interleukin 21 Receptor

IL-21R Products

IL-21R Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-21R/IL21R	Human	IL-21R/Interleukin-21 Receptor Protein, Recombinant	11483-H08H

  11483-H08H:  Measured by its ability to bind human IL-21 in a functional ELISA.

IL-21R Antibody

Molecule	Application	Description	Cat. No
Human IL-21R/IL21R	WB, ELISA	IL-21R Antibody (Antigen Affinity Purified)	11483-RP02

IL-21R cDNA Clone

Molecule	Species	Description	Cat. No
IL-21R/IL21R	Human	Homo sapiens IL-21R cDNA Clone	HG11483-M
IL-21R/IL21R	Rat	Rat IL-21R cDNA Clone	RG80189-G

IL-21R Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-21R/IL21R

IL-21R Alternative Names

IL-21R, IL21R, UNQ3121/PRO10273, MGC10967, NILR [Homo sapiens]

IL-21R, Il21r, NILR [Mus musculus]

IL-21R Background

Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.

IL-21R Related Studies

1. Asao H, et al. (2001) Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 167(1): 1-5.
2. Wu Z, et al. (2005) Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol. 25(22): 9741-52.
3. De Totero D, et al. (2006) Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood. 107(9): 3708-15.