Anti-IL21 Receptor Antibody

Cat: 11483-RP02
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All IL21 Receptor Reagents
Anti-IL21 Receptor Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL21 Receptor Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL21 Receptor
Immunogen
Recombinant Human IL-21R protein (Catalog#11483-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL-21R (rh IL-21R; Catalog#11483-H08H; Q9HBE5-1; Met 1-Pro 236). IL-21R specific IgG was purified by Human IL-21R affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL21 Receptor Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL21 Receptor Antibody Alternative Names
Anti-CD360 Antibody;Anti-NILR Antibody
IL21 Receptor Background Information

Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.

Full Name
interleukin 21 receptor
References
  • Asao H, et al. (2001) Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 167(1): 1-5.
  • Wu Z, et al. (2005) Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol. 25(22): 9741-52.
  • De Totero D, et al. (2006) Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood. 107(9): 3708-15.
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    Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA 90315-T16
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA 90315-RP01
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA 80189-T16
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA 51184-RP01
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA 51184-T16
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA 11483-T16
    Anti-IL21 Receptor Antibody Rabbit Monoclonal ELISA 11483-R033
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA 11483-RP01
    Anti-IL21 Receptor Antibody Rabbit Polyclonal ELISA,IHC-P 11483-T24
    Anti-IL21 Receptor Antibody Mouse Monoclonal ELISA 11483-MM06
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