All IL1RAP reagents are produced in house and quality controlled, including 8 IL1RAP Antibody, 28 IL1RAP Gene, 4 IL1RAP Lysate, 4 IL1RAP Protein, 2 IL1RAP qPCR. All IL1RAP reagents are ready to use.
Recombinant IL1RAP proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc & His, C-human IgG1-Fc.
IL1RAPantibodies are validated with different applications, which are WB, ELISA, FCM.
IL1RAPcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL1RAP of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.