IL-1RAcP Protein & Antibody (IL-1R3)

Interleukin-1 Receptor Accessory Protein

IL-1RAcP Products

IL-1RAcP Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-1RAcP/IL-1R3	Human	IL-1RAcP/IL-1R3/Fc Protein, Recombinant	10121-H03H
IL-1RAcP/IL-1R3	Human	IL-1RAcP/IL-1R3/Fc Protein, Recombinant	10121-H08H

IL-1RAcP Antibody Products

Molecule	Application	Description	Cat. No
Human IL-1RAcP/IL-1R3	WB, ELISA	Mouse Monoclonal Antibody	10121-MM05

IL-1RAcP cDNA Clone

Molecule	Species	Description	Cat. No
IL-1RAcP/IL-1R3	Human	Homo sapiens IL-1RacP/IL-1R3 cDNA Clone(NM_002182.2)	HG10121-M

IL-1RAcP Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1RAcP/IL-1R3

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL-1RAcP/IL-1R3

IL-1RAcP Alternative Names

IL-1RAcP, IL1R3, IL1RAP, C3orf13, FLJ37788, IL-1RAcP [Homo sapiens]

IL-1RAcP, Il1rap, 6430709H04Rik, AI255955, AV239853 [Mus musculus]

IL-1RAcP Background

Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

IL-1RAcP Related Studies

1. Goldbach-Mansky R, et al. (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol. 124(6): 1141-9.
2. Johnston A, et al. (2011) IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. J Immunol. 186(4): 2613-22.
3. Ozaki K, et al. (2001) Effect of tumor weight and tube feeding on TNF-alpha and IL-1beta mRNA expression in the brain of mice. JPEN J Parenter Enteral Nutr. 25(6): 317-22.