Quick Order

IL-1RAcP / IL-1R3 Antibody, Rabbit PAb, Antigen Affinity Purified

DatasheetReviewsRelated ProductsProtocols
Human IL1R3 Antibody Product Information
Immunogen:Recombinant Human IL-1RAcP / IL-1R3 protein (Catalog#10121-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human IL-1RAcP / IL-1R3 (rh IL-1RAcP / IL-1R3; Catalog#10121-H08H; NP_002173.1; Met 1-Glu 359). IL-1RAcP / IL-1R3 specific IgG was purified by Human IL-1RAcP / IL-1R3 affinity chromatography.
Human IL1R3 Antibody Usage Guide
Specificity:Human IL-1RAcP / IL-1R3
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL1R3. The detection limit for Human IL1R3 is approximately 0.0049 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IL1R3 Antibody Products
Reactivity: Human  
Application: ELISA  WB  
  • Slide 1
10121-T48-100
10121-T48-200
10121-T48-50
100 µg 
200 µg 
50 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10121-RP01-400
    10121-RP01-200
    10121-RP01-100
     
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  FCM  
    • Slide 1
    10121-MM05-200
    10121-MM05-50
    10121-MM05-100
    200 µg 
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10121-MM05-F-50
    10121-MM05-F-100
    50 Tests 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10121-MM04-100
      10121-MM04-50
      10121-MM04-200
      100 µg 
      50 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10121-MM05-A-100
      10121-MM05-A-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10121-MM05-P-100
      10121-MM05-P-50
      100 Tests 
      50 Tests 
      Add to Cart
      IL-1RAcP/IL-1R3 Background

      Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

      Human IL-1RAcP/IL-1R3 References
    • Goldbach-Mansky R, et al. (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol. 124(6): 1141-9.
    • Johnston A, et al. (2011) IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. J Immunol. 186(4): 2613-22.
    • Ozaki K, et al. (2001) Effect of tumor weight and tube feeding on TNF-alpha and IL-1beta mRNA expression in the brain of mice. JPEN J Parenter Enteral Nutr. 25(6): 317-22.
    • Product nameProduct name
      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"