Anti-IL1RAP Antibody

Cat: 10121-RP02
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All IL1RAP Reagents
Anti-IL1RAP Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL1RAP Antibody
Validated applications
Species reactivity
Reacts with: Human
Human IL1RAP
Recombinant Human IL-1RAcP / IL-1R3 protein (Catalog#10121-H08H)
Produced in rabbits immunized with purified, recombinant Human IL-1RAcP / IL-1R3 (rh IL-1RAcP / IL-1R3; Catalog#10121-H08H; NP_002173.1; Met 1-Glu 359). IL-1RAcP / IL-1R3 specific IgG was purified by Human IL-1RAcP / IL-1R3 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL1RAP Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL1RAP Antibody Alternative Names
Anti-C3orf13 Antibody;Anti-IL-1RAcP Antibody;Anti-IL1R3 Antibody
IL1RAP Background Information

Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Full Name
interleukin 1 receptor accessory protein
  • Goldbach-Mansky R, et al. (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol. 124(6): 1141-9.
  • Johnston A, et al. (2011) IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. J Immunol. 186(4): 2613-22.
  • Ozaki K, et al. (2001) Effect of tumor weight and tube feeding on TNF-alpha and IL-1beta mRNA expression in the brain of mice. JPEN J Parenter Enteral Nutr. 25(6): 317-22.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL1RAP Antibody (PE) Mouse Monoclonal FCM 10121-MM05-P
    Anti-IL1RAP Antibody Mouse Monoclonal ELISA 10121-MM04
    Anti-IL1RAP Antibody Rabbit Polyclonal WB,ELISA 10121-T48
    Anti-IL1RAP Antibody Mouse Monoclonal ELISA,FCM 10121-MM05
    Anti-IL1RAP Antibody (FITC) Mouse Monoclonal FCM 10121-MM05-F
    Anti-IL1RAP Antibody Rabbit Polyclonal ELISA 10121-RP01
    Anti-IL1RAP Antibody (APC) Mouse Monoclonal FCM 10121-MM05-A
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