Anti-IL1RAP Antibody

Cat: 10121-MM05
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Anti-IL1RAP Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IL1RAP Antibody
Validated applications
ELISA,FCM
Species reactivity
Reacts with: Human
Specificity
Human IL1RAP
Immunogen
Recombinant Human IL1R3 protein (Catalog#10121-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL1R3 / IL1RAP (rh IL1R3; Catalog#10121-H08H; NP_002173.1; Met 1-Glu 359). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2a Clone #7E4G1E8
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL1RAP Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL1RAP Antibody (Mouse Monoclonal antibody) Images
Human IL-1RAcP/IL-1R3 Flow Cytometry (FC) 5131
Flow cytometric analysis of Human IL1R3 expression on human whole blood monocytes. Cells were stained with purified anti-Human IL1R3, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable monocytes.
Anti-IL1RAP Antibody Alternative Names
Anti-C3orf13 Antibody;Anti-IL-1RAcP Antibody;Anti-IL1R3 Antibody
IL1RAP Background Information

Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Full Name
interleukin 1 receptor accessory protein
References
  • Goldbach-Mansky R, et al. (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol. 124(6): 1141-9.
  • Johnston A, et al. (2011) IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. J Immunol. 186(4): 2613-22.
  • Ozaki K, et al. (2001) Effect of tumor weight and tube feeding on TNF-alpha and IL-1beta mRNA expression in the brain of mice. JPEN J Parenter Enteral Nutr. 25(6): 317-22.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL1RAP Antibody Rabbit Polyclonal ELISA 10121-RP02
    Anti-IL1RAP Antibody (PE) Mouse Monoclonal FCM 10121-MM05-P
    Anti-IL1RAP Antibody Mouse Monoclonal ELISA 10121-MM04
    Anti-IL1RAP Antibody Rabbit Polyclonal WB,ELISA 10121-T48
    Anti-IL1RAP Antibody (FITC) Mouse Monoclonal FCM 10121-MM05-F
    Anti-IL1RAP Antibody Rabbit Polyclonal ELISA 10121-RP01
    Anti-IL1RAP Antibody (APC) Mouse Monoclonal FCM 10121-MM05-A
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