IL-1RA Protein & Antibody (IL-1F3, IL1RN)

Interleukin-1 Receptor Antagonist (IL-1 family member 3)

IL-1RA Products

IL-1RA Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1RA/IL-1F3	Human	IL-1RA/IL-1F3/Fc Protein, Recombinant	10123-H01H
IL-1RA/IL-1F3	Human	IL-1RA/IL-1F3 Protein, Recombinant, with Native	10123-HNAE

IL-1RA Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Huma IL-1RA/IL-1F3	WB, ELISA	IL-1RA/IL-1F3 Antibody, Rabbit MAb	10123-R001
Huma IL-1RA/IL-1F3	WB, FCM	IL-1RA Antibody ( FITC )	10123-R004-F
Huma IL-1RA/IL-1F3	WB, ELISA	IL-1RA/IL-1F3 Antibody, Mouse MAb	10123-MM12

IL-1RA cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1RA/IL-1F3	Human	Homo sapiens IL-1RA/IL-1F3 transcript variant 1 cDNA Clone(NM_173842.1)	HG10123-M
IL-1RA/IL-1F3	Human	IL1RN cDNA Clone / ORF Clone	HG13245-G
IL-1RA/IL-1F3	Rat	Rat IL-1RA/IL-1F3 cDNA Clone / ORF Clone	RG80073-M

IL-1RA Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1RA/IL-1F3

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL-1RA/IL-1F3

IL-1RA Alternative Names

IL-1RA, IL1F3, IL1RN, IL1RA, DIRA, ICIL-1RA, IL-1ra3, IRAP, MGC10430, MVCD4 [Homo sapiens]

IL-1ra, Il1rn, RP23-218B17.2, F630041P17Rik [Mus musculus]

IL-1RA Background

Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.

IL-1RA Related Studies

1. Langdahl BL, et al. (2000) Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene. J Bone Miner. 15 (3): 402-14.
2. El-Omar EM, et al. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 404 (6776): 398-402.
3. Steinkasserer A, et al. (1992) The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics. 13 (3): 654-7.