Anti-IL1RA Antibody (FITC)


**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.
Product Description | Host | Clonality | Application | Catalog# (PDF) |
---|---|---|---|---|
Anti-IL1RA Antibody | Rabbit | Monoclonal | ELISA | 10123-R001 |
Anti-IL1RA Antibody | Rabbit | Polyclonal | ELISA | 10123-RP01 |
Anti-IL1RA Antibody | Mouse | Monoclonal | FCM,ICC/IF,IF | 10123-MM02 |
Anti-IL1RA Antibody (FITC) | Rabbit | Monoclonal | FCM | 10123-R004-F |
Anti-IL1RA Antibody | Rabbit | Polyclonal | ELISA,IHC-P | 10123-RP02 |
Anti-IL1RA Antibody (PE) | Mouse | Monoclonal | FCM | 10123-MM02-P |
Anti-IL1RA Antibody | Rabbit | Monoclonal | IHC-P | 100099-R005 |
Anti-IL1RA Antibody | Mouse | Monoclonal | ELISA | 10123-MM12 |
Anti-IL1RA Antibody | Rabbit | Monoclonal | FCM,ICC/IF,IF | 10123-R004 |