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> IL-1R8 Protein (IL1RAPL1 Protein) IL-1R8 Protein (IL1RAPL1 Protein)
Interleukin-1 Receptor 8 / Interleukin 1 Receptor Accessory Protein-Like 1
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IL-1R8 / IL1RAPL1 Products
IL-1R8 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-1R8/IL1RAPL1 | Human | IL1RAPL1/IL-1R8/Fc Protein, Recombinant | 10177-H02H |
| IL-1R8/IL1RAPL1 | Human | IL1RAPL1/IL-1R8 Protein, Recombinant | 10177-H08H |
| IL-1R8/IL1RAPL1 | Mouse | IL-1R8 / IL1RAPL1 Protein, Recombinant | 50900-M02H |
IL-1R8 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-1R8/IL1RAPL1 | WB,ELISA | IL1RAPL1/IL-1R8 Antibody, Mouse MAb | 10177-MM06 |
IL-1R8 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-1R8/IL1RAPL1 | Human | Homo sapiens IL1RAPL1/IL-1R8 cDNA Clone(NM_014271.3) | HG10177-M |
| IL-1R8/IL1RAPL1 | Mouse | Mouse IL1RAPL1/IL-1R8 cDNA Clone / ORF Clone | MG50900-G |
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IL-1R8 / IL1RAPL1 Alternative Names
IL-1R8, IL1RAPL1, IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2
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IL-1R8 / IL1RAPL1 Related Areas
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL-1R8/IL1RAPL1
IL-1R8 Background
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.
IL-1R8 Related Studies
- Frédéric Gambino, et al. (2007) IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci. 104 (21): 9063-8.
- Wheway JM, et al. (2003) A complex deletion-inversion-deletion event results in a chimeric IL1RAPL1-dystrophin transcript and a contiguous gene deletion syndrome. J Med Genet. 40: 127-131.
