IL-1R2 Protein & Antibody (CD121b)

Interleukin 1 Receptor, type II (Cluster of Differentiation 121b)

IL-1R2 Products

IL-1R2 Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-1R2/CD121b	Human	IL-1R2/CD121b/Fc Protein, Recombinant	10111-H02H
IL-1R2/CD121b	Human	IL-1R2/CD121b Protein, Recombinant	10111-H08H
IL-1R2/CD121b	Rat	IL1R2 / IL1RB / CD121b Protein, Recombinant	80196-R08H

  10111-H02H:  Immobilized recombinant human IL1B at 2 µg/mL (100 µl/well) can bind recombinant human IL1R2-Fc with a linear range of 6.25–400 ng/ml. Measured by its binding ability in a functional ELISA.

IL-1R2 Antibody

Molecule	Application	Description	Cat. No
Human	WB	IL-1R2/CD121b Antibody, Mouse Mab	10111-MM09
Human	WB, ELISA	IL-1R2/CD121b Antibody, Rabbit MAb	10111-R020
Human	WB, ELISA	IL-1R2/CD121b Antibody, Rabbit PAb	10111-RP01
Human	WB, ELISA	IL-1R2/CD121b Antibody, Rabbit PAb (Antigen Affinity Purified)	10111-RP02
Human	WB, ELISA	IL-1R2/CD121b Antibody, Mouse MAb	10111-MM04

IL-1R2 ELISA Kit

Molecule	Application	Description	Cat. No
Human IL-1R2/CD121b	ELISA	IL-1R2/CD121b ELISA Kit	SEK10111

IL-1R2 cDNA Clone

Molecule	Species	Description	Cat. No
IL-1R2/CD121b	Human	IL1R2/CD121b transcript variant 1 cDNA Clone / ORF Clone	HG10111-M
IL-1R2/CD121b	Mouse	IL1R2 cDNA Clone / ORF Clone	MG51090-G
IL-1R2/CD121b	Rat	IL-1R2/CD121b transcript variant 1 cDNA Clone	RG80196-G
IL-1R2/CD121b	Rat	IL1R2 cDNA Clone / ORF Clone	KG90120-G

IL-1R2 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1R2/ CD121b

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 Superfamily and IL-1R/TLR Family>>IL-1R2/ CD121b

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> IL-1R2/CD121b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>IL-1R2/CD121b

IL-1R2 Alternative Names

CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1RB, MGC47725[Homo sapiens]

CD121b, Il1r-2 [Mus musculus]

CD121 antigen-like family member B, IL-1 type II receptor, IL-1R-2, IL-1R-beta, IL-1RT-2, IL-1RT2, interleukin-1 receptor beta [Rattus norvegicus]

IL-1R2 Background

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

IL-1R2 Related Studies

1. Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
2. Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
3. Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.