Anti-IL1R2 Antibody

Cat: 10111-MM04
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Anti-IL1R2 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IL1R2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL1R2
No cross-reactivity in ELISA with Human IL1RA Human IL1R1 Human IL1R3 Human IL1R4 Human IL1R8 Human IL1R9 Human IL18R1
Immunogen
Recombinant Human IL1R2 protein (Catalog#10111-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1R2 / CD121b (rh IL-1R2 / CD121b; Catalog#10111-H08H; NP_004624.1; Met 1-Glu 343). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #7H4D4F8
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL1R2 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL1R2 Antibody Alternative Names
Anti-CD121b Antibody;Anti-CDw121b Antibody;Anti-IL-1R-2 Antibody;Anti-IL-1RT-2 Antibody;Anti-IL-1RT2 Antibody;Anti-IL1R2c Antibody;Anti-IL1RB Antibody
IL1R2 Background Information

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

Full Name
interleukin 1 receptor, type II
References
  • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL1R2 Antibody Rabbit Monoclonal ELISA 80196-R021
    Anti-IL1R2 Antibody Rabbit Polyclonal ELISA 80196-RP01
    Anti-IL1R2 Antibody Mouse Monoclonal ELISA,ELISA(Det) 80196-MM05
    Anti-IL1R2 Antibody Rabbit Monoclonal ELISA(Cap) 80196-R161
    Anti-IL1R2 Antibody Rabbit Monoclonal ELISA 51090-R016
    Anti-IL1R2 Antibody Rabbit Polyclonal ELISA 51090-T16
    Anti-IL1R2 Antibody Rabbit Polyclonal ELISA 51090-RP01
    Anti-IL1R2 Antibody Rabbit Monoclonal ELISA 10111-R020
    Anti-IL1R2 Antibody Rabbit Polyclonal ELISA 10111-RP02
    Anti-IL1R2 Antibody Mouse Monoclonal ELISA 10111-MM11
    Anti-IL1R2 Antibody Rabbit Monoclonal ELISA(Cap) 10111-R041
    Anti-IL1R2 Antibody Rabbit Polyclonal ELISA 10111-RP01
    Anti-IL1R2 Antibody Mouse Monoclonal ELISA(Det) 10111-MM02
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