IL-1R1 Protein & Antibody (CD121a)

Interleukin 1 Receptor, type I (Cluster of Differentiation 121a)

IL-1R1 Products

IL-1R1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1R1/CD121a	Human	IL-1R1/Fc Protein, Recombinant	10126-H02H
IL-1R1/CD121a	Human	IL-1R1 Protein, Recombinant	10126-H08H
IL-1R1/CD121a	Mouse	IL-1R1 Protein, Recombinant	50807-M08H
IL-1R1/CD121a	Mouse	IL1R1 / CD121a Protein, Recombinant	50807-M02H
IL-1R1/CD121a	Rat	IL-1R1 Protein, Recombinant	80028-R06H
IL-1R1/CD121a	Rat	IL-1R1 Protein, Recombinant	80028-R08H

10126-H02H: Immobilized human IL1-beta at 20 µg/ml (100 µl/well) can bind human IL1R1 Fc chimera with a linear ranger of 6.4-160 ng/ml. Measured by its binding ability in a functional ELISA.

10126-H08H: Measured by its ability to bind human IL1-beta in a functional ELISA.

80028-R06H: The ED₅₀ for this effect is typically 5-20 µg/ml in the presence of 40 pg/mL of human IL1a. Measured by its ability to inhibit IL1αdependent proliferation in D10.G4.1 mouse helper T cells. （Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272.）

IL-1R1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-1R1/CD121a	WB, ELISA	Mouse Monoclonal Antibody	10126-MM10
Human IL-1R1/CD121a	WB, ELISA	Rabbit Polyclonal Antibody	10126-RP01
Human IL-1R1/CD121a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10126-RP02
Rat IL-1R1/CD121a	WB, ELISA	IL-1R1 / CD121a Antibody (Antigen Affinity Purified)	80028-RP02

IL-1R1 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-1R1/CD121a	ELISA	IL-1R1/CD121a ELISA Kit	SEK10126

IL-1R1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1R1/CD121a	Human	Homo sapiens IL-1R1 cDNA Clone(NM_000877.2)	HG10126-M
IL-1R1/CD121a	Mouse	Mouse IL-1R1/CD121a cDNA Clone / ORF Clone	MG50807-G
IL-1R1/CD121a	Rat	Rattus norvegicus IL-1R1 cDNA Clone	RG80028-M

IL-1R1 Related Areas

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>IL-1R1/CD121a

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1R1/CD121a

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 Superfamily and IL-1R/TLR Family>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Other>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL-1R1/CD121a

IL-1R1 Alternative Names

CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 [Homo sapiens]

CD121a, CD121b, IL-iR, Il1r-1, MGC129154 [Mus musculus]

CD121 antigen-like family member A; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; interleukin 1 beta receptor type 1 short [Rattus norvegicus]

IL-1R1 Background

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

IL-1R1 Related Studies

Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.

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