Anti-IL1R1 Antibody

Cat: 80028-RP02
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All IL1R1 Reagents
Anti-IL1R1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL1R1 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat IL1R1
Immunogen
Recombinant Rat IL-1R1 / CD121a protein (Catalog#80028-R08H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat IL-1R1 / CD121a (rR IL-1R1 / CD121a; Catalog#80028-R08H; NP_037255.3; Met 1-Lys 352). IL-1R1 / CD121a specific IgG was purified by Rat IL-1R1 / CD121a affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL1R1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL1R1 Antibody (Rabbit Polyclonal antibody) Images
Rat IL1R1/IL-1R1/IL-1 RI Western blot (WB) 13734

Anti-IL1R1 rabbit polyclonal antibody at 1:500 dilution

Lane A: Molt4 Whole Cell Lysate

Lane B: Jurkat Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:65 kDa

Observed band size:65 kDa

(We are unsure as to the identity of these extra bands.)

IL1R1 Background Information

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

Full Name
interleukin 1 receptor, type I
References
  • Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
  • Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
  • Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL1R1 Antibody Rabbit Polyclonal ELISA 90279-T16
    Anti-IL1R1 Antibody Mouse Monoclonal ELISA 90279-MM02
    Anti-IL1R1 Antibody (FITC) Rabbit Monoclonal FCM 80028-R007-F
    Anti-IL1R1 Antibody Mouse Monoclonal ELISA(Cap) 80028-MM10
    Anti-IL1R1 Antibody Mouse Monoclonal ELISA,ELISA(Det) 80028-MM08
    Anti-IL1R1 Antibody Rabbit Monoclonal ELISA,FCM 80028-R007
    Anti-IL1R1 Antibody Rabbit Polyclonal ELISA 80028-RP01
    Anti-IL1R1 Antibody (PE) Rabbit Monoclonal FCM 80028-R007-P
    Anti-IL1R1 Antibody Rabbit Monoclonal ELISA 80028-R027
    Anti-IL1R1 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 50807-R002
    Anti-IL1R1 Antibody Rabbit Polyclonal ELISA 50807-T16
    Anti-IL1R1 Antibody (APC) Rabbit Monoclonal FCM 50807-R191-A
    Anti-IL1R1 Antibody Rabbit Monoclonal ELISA 50807-R075
    Anti-IL1R1 Antibody Rabbit Monoclonal FCM 50807-R191
    Anti-IL1R1 Antibody (PE) Rabbit Monoclonal FCM 50807-R191-P
    Anti-IL1R1 Antibody Rabbit Polyclonal ELISA,IHC-P 50807-T24
    Anti-IL1R1 Antibody Rabbit Polyclonal ELISA 50807-RP01
    Anti-IL1R1 Antibody Mouse Monoclonal ELISA(Cap) 10126-MM08
    Anti-IL1R1 Antibody Mouse Monoclonal ELISA 10126-MM10
    Anti-IL1R1 Antibody Rabbit Polyclonal ELISA 10126-T16
    Anti-IL1R1 Antibody Rabbit Polyclonal ELISA 10126-RP01
    Anti-IL1R1 Antibody Rabbit Monoclonal ELISA 10126-R024
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