IL-1F6 / IL1F6 / IL36A Protein

Interleukin 1 family, member 6 (epsilon)

IL-1F6 Products

IL-1F6 Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-1F6/IL1F6	Human	IL1F6 / IL36A Protein, Recombinant, Native	10607-HNAE
IL-1F6/IL1F6	Human	IL1F6 / IL36A Protein, Recombinant	10607-H07E
IL-1F6/IL1F6	Mouse	IL-1F6/IL-1 epsilon Protein, Recombinant, Native	50095-HNAE

IL-1F6 Antibody

Molecule	Application	Description	Cat. No
Mouse IL-1F6/IL1F6	WB, ELISA	IL-1F6 Antibody (Antigen Affinity Purified)	50095-RP02

IL-1F6 cDNA Clone

Molecule	Species	Description	Cat. No
IL-1F6/IL1F6	Human	Homo sapiens IL-1F6 cDNA Clone	HG10607-M
IL-1F6/IL1F6	Mouse	Mus musculus IL-1F6 cDNA Clone	MG50095-M

IL-1F6 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>IL-1F6/IL1F6

IL-1F6 Alternative Names

IL-1F6, IL1F6, IL-1 epsilon, FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), MGC129552, MGC129553 [Homo sapiens]

IL-1F6, Il1f6, IL-1 epsilon, RP23-176J12.4, Fil1, IL-1H1, IL1RP2, Il1f9, MGC151479, MGC151481 [Mus musculus]

IL-1F6 Background

Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

IL-1F6 Related Studies

1. Tripodi D, et al. (2012) IL-36 a new member of the IL-1 family cytokines. J Biol Regul Homeost Agents. 26(1):7-14.
2. Towne JE, et al. (2004) Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J Biol Chem. 279(14): 13677-88.
3. Kumar S, et al. (2000) Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 275(14): 10308-14.