Anti-IL-1F6 Antibody

Cat: 50095-RP02
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All IL-1F6 Reagents
Anti-IL-1F6 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL-1F6 Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse IL-1F6
Recombinant Mouse IL-1F6 protein (Catalog#50095-HNAE)
Produced in rabbits immunized with purified, recombinant Mouse IL-1F6 (rM IL-1F6; Catalog#50095-HNAE; Q9JLA2-1; Met 1-His 160). IL-1F6 specific IgG was purified by Mouse IL-1F6 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-1F6 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-1F6 Antibody Alternative Names
Anti-FIL1 Antibody;Anti-FIL1(EPSILON) Antibody;Anti-FIL1E Antibody;Anti-IL-1F6 Antibody;Anti-IL1(EPSILON) Antibody;Anti-IL1F6 Antibody
IL-1F6 Background Information

Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

Full Name
interleukin 36, alpha
  • Tripodi D, et al. (2012) IL-36 a new member of the IL-1 family cytokines. J Biol Regul Homeost Agents. 26(1):7-14.
  • Towne JE, et al. (2004) Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J Biol Chem. 279(14): 13677-88.
  • Kumar S, et al. (2000) Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 275(14): 10308-14.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-1F6 Antibody Rabbit Polyclonal ELISA 50095-T16
    Anti-IL-1F6 Antibody Rabbit Monoclonal ELISA 50095-R572
    Anti-IL-1F6 Antibody Rabbit Polyclonal ELISA 50095-RP01
    Anti-IL-1F6 Antibody Rabbit Monoclonal ELISA 10607-R112
    Anti-IL-1F6 Antibody Rabbit Polyclonal WB,ELISA 10607-T48
    Anti-IL-1F6 Antibody Rabbit Polyclonal WB,ELISA,IP 10607-T52
    Anti-IL-1F6 Antibody Rabbit Polyclonal ELISA 10607-T16
    Anti-IL-1F6 Antibody Mouse Monoclonal ELISA 10607-MM04
    Anti-IL-1F6 Antibody Rabbit Polyclonal ELISA 10607-RP01
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