Anti-IL36RN Antibody

Cat: 50213-R022
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All IL36RN Reagents
Anti-IL36RN Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-IL36RN Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse IL36RN
Recombinant Mouse IL-1F5 protein (Catalog#50213-MNAE)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1F5 (rM IL-1F5; Catalog#50213-MNAE; NP_062324.2; Val3-Asp156).
Monoclonal Rabbit IgG Clone #022
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL36RN Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL36RN Antibody Alternative Names
Anti-AI413231 Antibody;Anti-Fil1delta Antibody;Anti-Il-1h3 Antibody;Anti-Il1hy1 Antibody;Anti-RP23-176J12.6 Antibody
IL36RN Background Information

Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR−/− mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.

Full Name
interleukin 36 receptor antagonist
  • Nicklin MJ, et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19 (2): 382-4.
  • Debets R, et al. (2001) Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J Immunol. 167 (3): 1440-6.
  • Costelloe C, et al. (2008) IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 105(5): 1960-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA,IHC-P 50213-T24
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 50213-RP01
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 50213-T16
    Anti-IL36RN Antibody Rabbit Monoclonal ELISA 10125-R002
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 10125-RP01
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 10125-T16
    Anti-IL36RN Antibody Mouse Monoclonal ELISA 10125-MM04
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