Anti-IL36RN Antibody

Cat: 50213-R022
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Anti-IL36RN Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-IL36RN Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse IL36RN
Immunogen
Recombinant Mouse IL-1F5 protein (Catalog#50213-MNAE)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1F5 (rM IL-1F5; Catalog#50213-MNAE; NP_062324.2; Val3-Asp156).
Source
Monoclonal Rabbit IgG Clone #022
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL36RN Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL36RN Antibody Alternative Names
Anti-AI413231 Antibody;Anti-Fil1delta Antibody;Anti-Il-1h3 Antibody;Anti-Il1hy1 Antibody;Anti-RP23-176J12.6 Antibody
IL36RN Background Information

Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR−/− mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.

Full Name
interleukin 36 receptor antagonist
References
  • Nicklin MJ, et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19 (2): 382-4.
  • Debets R, et al. (2001) Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J Immunol. 167 (3): 1440-6.
  • Costelloe C, et al. (2008) IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 105(5): 1960-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA,IHC-P 50213-T24
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 50213-RP01
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 50213-T16
    Anti-IL36RN Antibody Rabbit Monoclonal ELISA 10125-R002
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 10125-RP01
    Anti-IL36RN Antibody Rabbit Polyclonal ELISA 10125-T16
    Anti-IL36RN Antibody Mouse Monoclonal ELISA 10125-MM04
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