All IL18BP reagents are produced in house and quality controlled, including 8 IL18BP Antibody, 1 IL18BP ELISA, 23 IL18BP Gene, 3 IL18BP Lysate, 3 IL18BP Protein, 2 IL18BP qPCR. All IL18BP reagents are ready to use.
Recombinant IL18BP proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc & His.
IL18BPantibodies are validated with different applications, which are ELISA, WB, ELISA(Cap).
IL18BPcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL18BP of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL18BPELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.