IL-18BP Protein & Antibody

Interleukin-18 Binding Protein

IL-18BP Products

IL-18BP Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-18BP	Mouse	IL-18BP Protein, Recombinant	50206-M08H
IL-18BPa	Human	IL-18BPa/Fc Protein, Recombinant	10357-H03H
IL-18BPa	Human	IL-18BPa Protein, Recombinant	10357-H08H

IL-18BP Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse IL-18BP	ELISA	Rabbit Polyclonal Antibody	50206-RP01
Mouse IL-18BP	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50206-RP02
Human IL-18BPa	WB	Mouse Monoclonal Antibody	10357-MM01
Human IL-18BPa	ELISA	Mouse Monoclonal Antibody	10357-MM02
Human IL-18BPa	ELISA	Rabbit Polyclonal Antibody	10357-RP03
Human IL-18BPa	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10357-RP04

IL-18BP ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-18BPa	ELISA	IL-18BPa ELISA Kit	SEK10357

IL-18BP cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-18BP	Human	Homo sapiens IL-18BP cDNA Clone	HG10357-M
IL-18BP	Human	Mus musculus IL18BP cDNA Clone	MG50206-M

IL-18BP Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 superfamily and IL-1R/TLR family >>IL-18BP

IL-18BP Alternative Names

IL18BP, IL18BPa [Homo sapiens]

IL-18BP, Il18bp, Igifbp, MC54L [Mus musculus]

IL-18BP Background

Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

IL-18BP Related Studies

1. Novick D, et al.. (2001) A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 14(6): 334-42.
2. Mazodier K, et al.. (2005) Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 106(10): 3483-9.
3. Akira S. (2000) The role of IL-18 in innate immunity. Curr Opin Immunol. 12(1): 59-63.