Anti-IL18BP Antibody

Cat: 10357-RP04
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Anti-IL18BP Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL18BP Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL18BP
Immunogen
Recombinant Human IL18BP protein (Catalog#10357-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL18BP N-terminal domain (rhIL18BP; Catalog#10357-H08H; NP_001034748.1; Met 1-Gly 192). IL18BP specific IgG was purified by human IL18BP affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL18BP Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL18BP Antibody Alternative Names
Anti-IL18BPa Antibody
IL18BP Background Information

Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

Full Name
interleukin 18 binding protein
References
  • Novick D, et al.. (2001) A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 14(6): 334-42.
  • Mazodier K, et al.. (2005) Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 106(10): 3483-9.
  • Akira S. (2000) The role of IL-18 in innate immunity. Curr Opin Immunol. 12(1): 59-63.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 50206-T16
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 50206-RP01
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 50206-RP02
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 10357-T16
    Anti-IL18BP Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10357-MM02
    Anti-IL18BP Antibody Rabbit Monoclonal ELISA 10357-R224
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 10357-RP03
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