Anti-IL18BP Antibody

Cat: 10357-MM02

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All IL18BP Reagents
Anti-IL18BP Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IL18BP Antibody
Validated applications
Species reactivity
Reacts with: Human
Human IL18BP
Human cell-derived rhIL18BPa (Catalog#10357-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL18BPa N-terminal domain (rhIL18BPa; Catalog#10357-H08H; NP_001034748.1; Met 1-Gly 192). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG2b Clone #7A11C11G1
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL18BP Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Cap) 1:250-1:2000 This antibody will detect Human IL18BP / IL18BPa in ELISA pair set (Catalog: # SEKA10357). In a sandwich ELISA, it can be used as capture antibody.

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL18BP Antibody Alternative Names
Anti-IL18BPa Antibody
IL18BP Background Information

Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

Full Name
interleukin 18 binding protein
  • Novick D, et al.. (2001) A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 14(6): 334-42.
  • Mazodier K, et al.. (2005) Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 106(10): 3483-9.
  • Akira S. (2000) The role of IL-18 in innate immunity. Curr Opin Immunol. 12(1): 59-63.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 50206-T16
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 50206-RP01
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 50206-RP02
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 10357-RP04
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 10357-T16
    Anti-IL18BP Antibody Rabbit Monoclonal ELISA 10357-R224
    Anti-IL18BP Antibody Rabbit Polyclonal ELISA 10357-RP03
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