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> IL-18 Protein IL-18 Protein
Interleukin 18
IL-18 Products
IL-18 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-18/IL18 | Cynomolgus | IL-18 Protein, Recombinant |
90011-C07E |
90011-C07E: Measured by its ability to bind human IL18R1 in a functional Elisa.
IL-18 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Cynomolgus IL-18/IL18 | WB, ELISA | IL-18 Antibody | 90011-MM02 |
| Cynomolgus IL-18/IL18 | WB, ELISA | IL-18 Antibody (Antigen Affinity Purified) | 90011-RP02 |
IL-18 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-18/IL18 | Human | IL18 cDNA Clone / ORF Clone | HG10119-M |
| IL-18/IL18 | Mouse | IL18 cDNA Clone / ORF Clone | MG50073-M |
| IL-18/IL18 | Canine | IL18 cDNA Clone / ORF Clone | CG70020-G |
| IL-18/IL18 | Rat | IL-18 cDNA Clone / ORF Clone | RG80072-M |
| IL-18/IL18 | Cynomolgus | IL-18 cDNA Clone / ORF Clone | KG90011-M |
IL-18 Related Areas
Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-18/IL18
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>IL-18/IL18
IL-18 Alternative Names
IL-18, IL18, IGIF, IL-1g, IL1F4, MGC12320 [Homo sapiens]
Il-18, Il18, Igif [Mus musculus]
IL-18 Background
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.
IL-18 Related Studies
- Dinarello CA. (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 103: 11-24.
- Takeda K, et al.. (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8(3): 383-90.
- Gracie JA, et al.. (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104(10): 1393-401.