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IL18/IL-18/Interleukin 18 Rabbit PAb

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    Mouse IL18 Antibody Product Information
    Immunogen:Recombinant Mouse IL-18 protein (Catalog#50073-MNAE)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse IL-18 (rM IL-18; Catalog#50073-MNAE; P70380; Asn36-Ser192). Total IgG was purified by Protein A affinity chromatography.
    Other IL18 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10119-R011-50
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      Reactivity: Human  
      Application: ELISA  
        10119-RP01-100
        10119-RP01-400
        10119-RP01-200
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        Reactivity: Human  
        Application: ELISA  WB  IP  
        • Slide 1
        10119-T52-200
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        10119-T52-100
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        Reactivity: Human  
        Application: ELISA  
          10119-T16-100
          10119-T16-50
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          100 µg 
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          Reactivity: Mouse  
          Application: ELISA  
            50073-T16-200
            50073-T16-100
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            200 µg 
            100 µg 
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            Reactivity: Mouse  
            Application: ELISA  
              50073-R167-100
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              100 µg 
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              Reactivity: Cynomolgus  
              Application: ELISA  
                90011-RP01-400
                90011-RP01-200
                90011-RP01-100
                 
                200 µg 
                100 µg 
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                Reactivity: Cynomolgus  
                Application: WB  IP  
                • Slide 1
                • Slide 1
                90011-RP02-50
                90011-RP02-100
                90011-RP02-200
                50 µg 
                100 µg 
                200 µg 
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                Reactivity: Cynomolgus  
                Application: ELISA  
                  90011-MM17-100
                  90011-MM17-50
                  90011-MM17-200
                  100 µg 
                  50 µg 
                  200 µg 
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                  Reactivity: Rhesus  
                  Application: ELISA  
                    90011-MM02-50
                    90011-MM02-100
                    90011-MM02-200
                    50 µg 
                    100 µg 
                    200 µg 
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                    IL18/IL-18/Interleukin 18 Background

                    Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

                    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                    Mouse IL18/IL-18/Interleukin 18 References
                  • Dinarello CA. (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 103: 11-24.
                  • Takeda K, et al.. (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8(3): 383-90.
                  • Gracie JA, et al.. (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104(10): 1393-401.
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                    Catalog: 50073-RP01-400
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                    Datasheet & Documentation

                    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"