IL-17RD Protein & Antibody (SEF)

Interleukin-17 Receptor D (Similar Expression to Fgf genes)

IL-17RD Products

IL-17RD Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-17RD	Human	IL-17RD Protein, Recombinant	10507-H08H

IL-17RD Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-17RD	WB, ELISA	IL-17RD Antibody, Rabbit Mab	10507-R010
Human IL-17RD	ELISA	Rabbit Polyclonal Antibody	10507-RP01
Human IL-17RD	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10507-RP02

IL-17RD Elisa Pair Set

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-17RD	ELISA	IL-17RD Elisa Pair Set	SEK10507

IL-17RD cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-17RD	Human	Homo sapiens IL-17RD cDNA Clone(NM_017563.3)	HG10507-M

IL-17RD Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-17RD

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-17 Family & IL-17 Receptor Family>>IL-17RD

IL-17RD Alternative Names

IL-17RD, IL17RD, SEF, DKFZp434N1928, FLJ35755, IL17RLM, MGC133309 [Homo sapiens]

Il17rd, 2810004A10Rik, Sef, Sef-S, AI428510, MGC118454 [Mus musculus]

IL-17RD Background

Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of interleukine-17 recepter family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD is found expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. IL-17RD is also expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, IL-17RD is expressed in the tongue and in the mesenchyme of the first branchial arch. It is also expressed in the developing inner ear. IL-17RD interacts with both IL-17R-Myc and IL-17RB-Myc. Both the intracellular and extracellular domains of IL-17RD interact with IL-17R. IL-17R forms a heteromeric complex with IL-17RD. Experiment results indicate that IL-17RD is able to affect IL-17R localization, suggesting that these two molecules are colocalized and associate with each other within cells. The fact that IL-17RD Delta ICD is unable to mediate IL-17 signaling but functions as a dominant-negative form indicates that the intracellular domain of IL-17RD is pivotal. In addition, IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.

IL-17RD Related Studies

1. Weaver CT, et al.. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol. 25: 821-52.
2. Rong Z, et al.. (2009) IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res. 19(2): 208-15.
3. Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9(8): 556-67.