IL17RB (Protein | Antibody | cDNA Clone | ELISA Kit)

All IL17RB reagents are produced in house and quality controlled, including 5 IL17RB Antibody, 52 IL17RB Gene, 6 IL17RB Lysate, 6 IL17RB Protein, 3 IL17RB qPCR. All IL17RB reagents are ready to use.

IL17RB Protein (6)

IL17RB Antibody (5)

IL17RB cDNA Clone (52)

NM_018725.3
NM_019583.3
NM_001107290.1
XM_001082504.2

IL17RB Lysate (6)

IL17RB Background

IL17RB is the receptor for IL17E, the only member of IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and short survival of the breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in the cell growth, proliferation and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics.

IL17RB References

  • Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
  • Stock P, et al.. (2009) Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 182(8): 5116-22.
  • Wang H, et al.. (2010) Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clin Exp Allergy. 40(8): 1194-202.