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> IL-17RB / IL-17BR Protein IL-17RB / IL-17BR Protein
Interleukin 17 Receptor B
IL-17RB / IL-17BR Products
IL-17RB / IL-17BR Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-17RB/IL-17BR | Human | IL-17RB/IL-17BR Protein, Recombinant, with Flag Tag | 13091-H25B |
IL-17RB / IL-17BR cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| IL-17RB/IL-17BR | Human | Human IL17Rb cDNA Clone / ORF Clone | HG13091-M |
| IL-17RB/IL-17BR | Mouse | Mouse IL17RB Gene cDNA Clone / ORF Clone | MG51109-G |
| IL-17RB/IL-17BR | Rat | Rat IL17RB cDNA Clone / ORF Clone | RG80188-G |
| IL-17RB/IL-17BR | Cynomolgus | Cynomolgus monkey IL17RB cDNA Clone / ORF Clone | CG90140-G |
IL-17RB / IL-17BR Related Areas
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-17 Family & IL-17 Receptor Family>>IL-17RB/IL-17BR
IL-17RB / IL-17BR Alternative Names
IL-17RB, IL-17BR, IL17RB, IL17BR, UNQ2501/PRO19612, CRL4, EVI27, IL17RH1, MGC5245 [Homo sapiens]
IL-17RB, IL-17BR, Il17rb, Il17br, Evi27, IL-17ER, IL-17Rh1, IL17RH1 [Mus musculus]
IL-17RB / IL-17BR Background
Interleukin-17 receptor B (IL-17RB/IL-17BR), also known as IL-17 receptor B, Cytokine receptor-like 4, and IL-17 receptor homolog 1, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Treatment with antagonistic mAbs to either IL-17RB or IL-17RA completely blocked IL-25-induced pulmonary inflammation and airway hyperresponsiveness in naive BALB/c mice, similar to the effects of an antagonistic Ab to IL-25. Thus IL-25-mediated activities require both IL-17RB and IL-17RA and provide another example of an IL-17 family ligand that utilizes a heteromeric receptor complex. IL-17RB/IL-17BR had been found increased on allergen-challenged basophil which is regulated by IL-3. This increasing inhibits apoptosis and promotes IgE-mediated degranulation of basophils.
IL-17RB / IL-17BR Related Studies
- Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
- Stock P, et al.. (2009) Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 182(8): 5116-22.
- Wang H, et al.. (2010) Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clin Exp Allergy. 40(8): 1194-202.
