**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-IL17RA Antibody (PE)||Mouse||Monoclonal||FCM||10895-MM06-P|
|IL-17R / IL-17RA / CD217 Neutralizing Antibody||Rabbit||Monoclonal||FCM,Neutralization||10895-R004|
|Anti-IL17RA Antibody (FITC)||Mouse||Monoclonal||FCM||10895-MM06-F|
|Anti-IL17RA Antibody (FITC)||Rabbit||Monoclonal||FCM||10895-R004-F|
|Anti-IL17RA Antibody (APC)||Mouse||Monoclonal||FCM||10895-MM06-A|