Anti-IL17RA Antibody

Cat: 10895-MM06
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All IL17RA Reagents
Anti-IL17RA Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IL17RA Antibody
Validated applications
ELISA,FCM
Species reactivity
Reacts with: Human
Specificity
Human IL17RA
Immunogen
Recombinant Human IL17RA protein (Catalog#10895-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL17RA (rh IL17RA; Catalog#10895-H08H; NP_055154.3; Met 1-Trp 320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #1H3C5
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL17RA Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL17RA Antibody (Mouse Monoclonal antibody) Images
Human IL17RA Flow Cytometry (FC) 19145
Flow cytometric analysis of Human IL17RA(CD217) expression on human whole blood granulocytes. Cells were stained with purified anti-Human IL17RA(CD217), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.
Anti-IL17RA Antibody Alternative Names
Anti-CANDF5 Antibody;Anti-CD217 Antibody;Anti-CDw217 Antibody;Anti-hIL-17R Antibody;Anti-IL-17RA Antibody;Anti-IL17R Antibody
IL17RA Background Information

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Full Name
interleukin 17 receptor A
References
  • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
  • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
  • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL17RA Antibody Rabbit Polyclonal ELISA 80190-RP01
    Anti-IL17RA Antibody Rabbit Polyclonal ELISA 80190-T16
    Anti-IL17RA Antibody Mouse Monoclonal ELISA 80190-MM05
    Anti-IL17RA Antibody Rabbit Polyclonal ELISA 50328-RP02
    Anti-IL17RA Antibody Rabbit Monoclonal ELISA 10895-R012
    Anti-IL17RA Antibody Rabbit Polyclonal ELISA 10895-T16
    Anti-IL17RA Antibody (PE) Mouse Monoclonal FCM 10895-MM06-P
    IL-17R / IL-17RA / CD217 Neutralizing Antibody Rabbit Monoclonal FCM,Neutralization 10895-R004
    Anti-IL17RA Antibody Rabbit Polyclonal ELISA 10895-RP01
    Anti-IL17RA Antibody (FITC) Mouse Monoclonal FCM 10895-MM06-F
    Anti-IL17RA Antibody (APC) Mouse Monoclonal FCM 10895-MM06-A
    Anti-IL17RA Antibody Mouse Monoclonal WB 10895-MM07
    Anti-IL17RA Antibody (FITC) Rabbit Monoclonal FCM 10895-R004-F
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