IL-16 Protein & Antibody
IL-16 Protein, Recombinant
10944-H07E: Measured by its ability to bind recombinant human CD4 in a functional ELISA.
IL-16 cDNA Clone
IL-16 Related Areas
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-16
IL-16 Alternative Names
IL-16, IL16, FLJ16806, FLJ42735, FLJ44234, LCF, NIL16, PRIL16, prIL-16 [Homo sapiens]
IL-16, Il16, KIAA4048, mKIAA4048 [Mus musculus]
Interleukin 16(IL-16), also known as pro-interleukin-16, is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. IL-16 undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. IL-16 is produced by CD8+ lymphocytes and has been reported to inhibit HIV-1 and SIV replication in infected PBMCs. CD4 serves as a receptor for the secreted form of IL-16, and IL-16 binding to CD4 induces signal transduction, which affects the activation state of the cell. We hypothesized, therefore, that the effect of IL-16 on HIV-1 replication might occur at the level of virus expression. In transient transfection studies with HIV-1 LTR-reporter gene constructs we found that pretreatment of CD4+ lymphoid cells with recombinant IL-16 repressed HIV-1 promoter activity up to 60-fold, preventing both PMA and Tat activation. This effect of IL-16 required sequences contained within the core enhancer, but was not simply due to the down-regulation of transcription factors binding to this element.
IL-16 Related Studies
- Maciaszek JW, et al. (1997) IL-16 represses HIV-1 promoter activity. J Immunol. 158(1): 5-8.
- Zhou P, et al. (1997) Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med. 3(6): 659-64.
- Theodore AC, et al. (1996) CD4 ligand IL-16 inhibits the mixed lymphocyte reaction. J Immunol. 157(5): 1958-64.
Interleukin Signaling Related Molecules