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IL15/IL-15/Interleukin 15  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
10360-HNCE-50
10360-HNCE-10
50 µg 
10 µg 
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Expression host: E. coli  
10360-H07E-5
10360-H07E-100
10360-H07E-10
5 µg 
100 µg 
10 µg 
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IL15/IL-15/Interleukin 15 Related Area

IL15/IL-15/Interleukin 15 Related Protein, Antibody, cDNA Gene, and ELISA Kits

IL15/IL-15/Interleukin 15 Summary & Protein Information

IL15/IL-15/Interleukin 15 Background

Subcellular location: Isoform IL15-S48AA: Secreted.; Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
Tissue specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Sequence similarity: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
General information above from UniProt

The protein encoded by IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL15/IL-15/Interleukin 15 Alternative Name

IL-15, [homo-sapiens]
interleukin 15,IL15,IL-15, [human]
interleukin 15,Il15,AI503618,IL-15, [mouse]
IL-15,AI503618, [mus-musculus]

IL15/IL-15/Interleukin 15 Related Studies

  • Mongini PKA, Gupta R, Boyle E, et al. TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells. Journal of immunology (Baltimore, Md : 1950). 2015;195(3):901-923.
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