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IL13 / ALRH Protein, Antibody, ELISA Kit, cDNA Clone

Mouse IL13 / ALRH Protein

Expression host: Human Cells
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50225-MNAH-100
50225-MNAH-5
50225-MNAH-20
100 µg / $698
5 µg / $38
20 µg / $178
Add to Cart

Human IL13 / ALRH Protein

Description: Active
Expression host: Human Cells
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10369-H01H-10
10369-H01H-20
10 µg / $108
20 µg / $198
Add to Cart
Description: Active
Expression host: CHO Stable Cells
  • Slide 1
10369-HNAC-5
10369-HNAC-500
10369-HNAC-100
10369-HNAC-1
10369-HNAC-20
5 µg / $58
500 µg / $2498
100 µg / $698
1 mg / $4148
20 µg / $198
Add to Cart

Cynomolgus IL13 / ALRH Protein

Description: Active
Expression host: Human Cells
  • Slide 1
  • Slide 1
11057-CNAH-100
11057-CNAH-20
11057-CNAH-500
11057-CNAH-5
11057-CNAH-1
100 µg / $398
20 µg / $138
500 µg / $1248
5 µg / $38
1 mg / $2098
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
11057-C07H-5
11057-C07H-100
11057-C07H-20
5 µg / $38
100 µg / $698
20 µg / $178
Add to Cart

IL13 / ALRH Related Areas

IL13 / ALRH Related Pathways

IL13 / ALRH Related Product

    IL13 / ALRH Summary & Protein Information

    IL13 / ALRH Related Information

    IL13 / ALRH Background

    Gene Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
    General information above from NCBI
    Subunit structure: Interacts with IL13RA2.
    Subcellular location: Secreted.
    Involvement in disease: Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the IL-4/IL-13 family.
    General information above from UniProt

    Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.

    IL13 / ALRH Alternative Name

    IL13 / ALRH Related Studies

  • Junttila IS, et al. (2008) Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 205(11): 2595-608.
  • Shimamura T,et al. (2008) Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J Immunol. 181(7): 4656-65.
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