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Mouse IL13 / ALRH Protein
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Mouse IL13 / ALRH Protein (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
50225-MNAH  

YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Interleukin 13 Protein Datasheet

 

IL-13 / Interleukin-13 Protein Price Inquiry ( Available Sizes )

IL-13 / Interleukin-13 Protein Product Information

Synonym : IL13, Il-13
Protein Construction:

A DNA sequence encoding the mouse IL13 (P20109) (Pro22-Phe131)  was expressed and purified.

Source: Mouse
Expression Host: Human Cells

IL-13 / Interleukin-13 Protein QC Testing

Purity: > 90 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

IL-13 / Interleukin-13 protein

Bio-activity:

Measured in a cell proliferation assay using TF1 human erythroleukemic cells (Kitamura, T. et al. (1989) J. Cell Physiol. 140:323.).
The ED50 for this effect is typically 2-10 ng/mL.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Pro 22
Molecular Mass:

The recombinant mouse IL13 consists of  110 amino acids and predicts a molecular mass of 12.1 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH7.5.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

IL-13 / Interleukin-13 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL-13 / Interleukin-13 Protein Related Products & Topics

Related Areas:

Proteins:

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-13

Immunology>>Adaptive Immunity>>B Cell>>IL-13

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-13

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-13

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IL-13/ALRH Human IL-13/ALRH/Fc Protein, Recombinant 10369-H01H
IL-13/ALRH Human IL-13/ALRH Protein, Recombinant, with Native 10369-HNAC
IL-13/ALRH Mouse IL-13 / Interleukin-13 Protein, Recombinant, with Native 50225-MNAH
IL-13/ALRH Cynomolgus IL-13/ALRH Protein, Recombinant, with Native 11057-CNAH
IL-13/ALRH Cynomolgus IL-13/ALRH Protein, Recombinant 11057-C07H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human IL-13 ELISA Mouse Monoclonal Antibody 10369-MM01
Human IL-13 WB Mouse Monoclonal Antibody 10369-MM02
Human IL-13 WB, ELISA IL13 / ALRH Antibody (Antigen Affinity Purified) 10369-RP02
Human IL-13 WB, ELISA IL13 / ALRH Antibody 10369-R062
Cynomolgus IL-13 WB Rabbit Polyclonal Antibody 11057-RP02

Antibodies:

IL-13 / Interleukin-13 Protein Description

Interleukin-13, also known as IL-13 and NC30, is a secreted protein which belongs to the IL-4 / IL-13 family It is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. Interleukin-13 / IL-3 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL13 is more importantly implicated as a central mediator of immunoregulatory processes in various cell types. Interleukin-13 / IL-3 is involved in several stages of B-cell maturation and differentiation including up-regulating CD23, CD71, CD72, and MHC class II expression, and promoting IgE isotype switching. Interleukin-13 / IL-3 inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. Interleukin-13 / IL-3 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL13 Rα1 and IL13 Rα2). Most of the biological effects of Interleukin-13 / IL-3, like those of IL-4, are linked to signal transducer and activator of transcription 6 (STAT6). Interleukin-13 / IL-3 is associated primarily with the pathophysiology of atopic respiratory diseases such as allergic asthma. In addition, studies have identified IL13 expression as a common feature of cHL (classical Hodgkin lymphoma). Defects in IL-13 may be a cause of susceptibility to allergic rhinitis (ALRH) which is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

References

  1. Minty A. et al., 1993, Nature. 362: 248-50.
  2. Sironi M. et al., 1994, Blood. 84: 1913-21.
  3. Solymar DC. et al., 2002, Immunity. 17: 41-50.
  4. Skinnider BF. et al., 2002, Leuk Lymphoma. 43: 1203-10.
  5. Monticelli S. et al., 2004, J Biol Chem. 279: 36210-8.
 

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Recommended Interleukin Antibodies

Product name Product name
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"