- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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Interleukin 13 Protein Datasheet
IL-13 / Interleukin-13 Protein Price Inquiry ( Available Sizes )
IL-13 / Interleukin-13 Protein Product Information
|Synonym :||IL13, Il-13|
A DNA sequence encoding the mouse IL13 (P20109) (Pro22-Phe131) was expressed and purified.
|Expression Host:||Human Cells|
IL-13 / Interleukin-13 Protein QC Testing
|Purity:||> 90 % as determined by SDS-PAGE||SDS-PAGE:
IL-13 / Interleukin-13 protein
|Measured in a cell proliferation assay using TF1 human erythroleukemic cells (Kitamura, T. et al. (1989) J. Cell Physiol. 140:323.).
The ED50 for this effect is typically 2-10 ng/mL.
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Pro 22|
The recombinant mouse IL13 consists of 110 amino acids and predicts a molecular mass of 12.1 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.5.
IL-13 / Interleukin-13 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
IL-13 / Interleukin-13 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|IL-13/ALRH||Human||IL-13/ALRH/Fc Protein, Recombinant||10369-H01H|
|IL-13/ALRH||Human||IL-13/ALRH Protein, Recombinant, with Native||10369-HNAC|
|IL-13/ALRH||Mouse||IL-13 / Interleukin-13 Protein, Recombinant, with Native||50225-MNAH|
|IL-13/ALRH||Cynomolgus||IL-13/ALRH Protein, Recombinant, with Native||11057-CNAH|
|IL-13/ALRH||Cynomolgus||IL-13/ALRH Protein, Recombinant||11057-C07H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human IL-13||ELISA||Mouse Monoclonal Antibody||10369-MM01|
|Human IL-13||WB||Mouse Monoclonal Antibody||10369-MM02|
|Human IL-13||WB, ELISA||IL13 / ALRH Antibody (Antigen Affinity Purified)||10369-RP02|
|Human IL-13||WB, ELISA||IL13 / ALRH Antibody||10369-R062|
|Cynomolgus IL-13||WB||Rabbit Polyclonal Antibody||11057-RP02|
IL-13 / Interleukin-13 Protein Description
Interleukin-13, also known as IL-13 and NC30, is a secreted protein which belongs to the IL-4 / IL-13 family It is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. Interleukin-13 / IL-3 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL13 is more importantly implicated as a central mediator of immunoregulatory processes in various cell types. Interleukin-13 / IL-3 is involved in several stages of B-cell maturation and differentiation including up-regulating CD23, CD71, CD72, and MHC class II expression, and promoting IgE isotype switching. Interleukin-13 / IL-3 inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. Interleukin-13 / IL-3 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL13 Rα1 and IL13 Rα2). Most of the biological effects of Interleukin-13 / IL-3, like those of IL-4, are linked to signal transducer and activator of transcription 6 (STAT6). Interleukin-13 / IL-3 is associated primarily with the pathophysiology of atopic respiratory diseases such as allergic asthma. In addition, studies have identified IL13 expression as a common feature of cHL (classical Hodgkin lymphoma). Defects in IL-13 may be a cause of susceptibility to allergic rhinitis (ALRH) which is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
- Minty A. et al., 1993, Nature. 362: 248-50.
- Sironi M. et al., 1994, Blood. 84: 1913-21.
- Solymar DC. et al., 2002, Immunity. 17: 41-50.
- Skinnider BF. et al., 2002, Leuk Lymphoma. 43: 1203-10.
- Monticelli S. et al., 2004, J Biol Chem. 279: 36210-8.
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