Anti-IL10RB Antibody

Cat: 10945-RP02
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All IL10RB Reagents
Anti-IL10RB Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL10RB Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL10RB
Immunogen
Recombinant Human IL10RB protein (Catalog#10945-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL10RB extracellular domain (rh IL10RB; Catalog#10945-H08H; NP_000619.3; Met 1-Ser 220). IL10RB specific IgG was purified by human IL10RB affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL10RB Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL10RB Antibody Alternative Names
Anti-CDW210B Antibody;Anti-CRF2-4 Antibody;Anti-CRFB4 Antibody;Anti-D21S58 Antibody;Anti-D21S66 Antibody;Anti-IL-10R2 Antibody
IL10RB Background Information

Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Full Name
interleukin 10 receptor, beta
References
  • Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.
  • Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL10RB Antibody Rabbit Monoclonal ELISA,ELISA(Det) 50846-R074
    Anti-IL10RB Antibody Rabbit Monoclonal ELISA(Cap) 50846-R009
    Anti-IL10RB Antibody Rabbit Polyclonal WB,ELISA 50846-RP02
    Anti-IL10RB Antibody Rabbit Polyclonal ELISA 50846-RP01
    Anti-IL10RB Antibody Rabbit Polyclonal ELISA 50846-T16
    Anti-IL10RB Antibody Mouse Monoclonal ELISA(Cap) 10945-MM01
    Anti-IL10RB Antibody Mouse Monoclonal ELISA 10945-MM02
    Anti-IL10RB Antibody Rabbit Polyclonal ELISA 10945-RP01
    Anti-IL10RB Antibody Rabbit Polyclonal WB,ELISA 10945-T48
    Anti-IL10RB Antibody Rabbit Polyclonal ELISA 10945-T16
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