IL10RA cDNA ORF Clone in Cloning Vector, Human
Cat: HG10419-M
Cat: HG10419-M
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IL10RA cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1737 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutation 459A/G not causing the amino acid variation.
Description
Full length Clone DNA of Human interleukin 10 receptor, alpha (IL10RA).
Plasmid
Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
IL10RA cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
IL10RA cDNA ORF Clone in Cloning Vector, Human: Alternative Names
CD210 cDNA ORF Clone, Human; CD210a cDNA ORF Clone, Human; CDW210A cDNA ORF Clone, Human; HIL-10R cDNA ORF Clone, Human; IL-10R1 cDNA ORF Clone, Human; IL10R cDNA ORF Clone, Human
IL10RA Background Information
CD21, also known as IL1RA, is a receptor for interleukin 1. CD21 has been shown to mediate the immunosuppressive signal of interleukin 1, and thus inhibits the synthesis of proinflammatory cytokines. It is structurally related to IFN receptors. It has been reported that CD21 promotes survival of progenitor myeloid cells. Activation of CD21 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
Full Name
interleukin 10 receptor, alpha
Research Areas
- Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10 Family & Receptor>>IL-10 Family Receptor
- Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>IL-10/Interferon Family
- Immunology>>Innate Immunity>>Cytokine>>Interleukins
- Immunology>>Inflammation / Inflammatory Mediator>>Neuroinflammation
- Cancer>>Signal Transduction>>Jak/STAT Signaling>>Receptors in the Jak/STAT Pathway
References
- Josephson K, et al. (2001) Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1. Acta Crystallogr D Biol Crystallogr. 57(Pt 12): 1908-11.
- Tan, J C, et al. (1995) Characterization of recombinant extracellular domain of human interleukin-10 receptor. J Biol Chem. 270(21):12906-11.
- Josephson, K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15(1):35-46.
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Related Pathways
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AKT Signaling Pathway -
Jak-Stat Signaling Pathway -
Autophagy Pathway
