IL-10 cDNA ORF Clone in Cloning Vector, Human

IL-1 is a anti-inflammatory cytokine which belongs to the IL-1 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-1 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-1 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-1 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 1 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-1. IL-1 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.

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interleukin 10

• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Disorders Therapeutic Targets>>Asthma Therapeutic Targets
• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>IL-1 Family
• Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10 Family & Receptor>>IL-10 Family Ligand
• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>IL-10/Interferon Family
• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>IL-12 Family
• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Mediators
• Immunology>>Innate Immunity>>Cytokine>>Interleukins
• Cancer>>Cancer Types>>Lymphoma
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Macrophage Markers
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Monocyte Markers
• Immunology>>Inflammation / Inflammatory Mediator>>Cells Involved in Inflammation>>Monocyte/Macrophage
• Immunology>>Inflammation / Inflammatory Mediator>>Cells Involved in Inflammation>>Myeloid-derived Suppressor Cells (MDSC)
• Immunology>>Inflammation / Inflammatory Mediator>>Neuroinflammation
• Stem Cells>>Stem Cell Growth Factors,Chemokines and Cytokines>>other stem cell-related Growth Factors, Chemokines and Cytokines
• Immunology>>Adaptive Immunity>>Regulatory T Cells
• Microbiology>>Pathogenic microorganism>>viruses>>Animal virus>>RNA virus>>-ssRNA virus>>Paramyxoviridae>>Human Respiratory Syncytial Virus (RSV)>>RSV infection associated>>RSV infection related

• Arimoto T, et al. (2007) Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 28(6):894-906.
• Han X, et al. (2010) Effect of cobalt protoporphyrin on hyperexpression of heme oxygenase-1 and secretion of IL-10 in rat bone marrow mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18(5):1297-301.
• Cui QQ, et al. (2011) Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 77(7): 1436-41.