IL-10 Protein

Interleukin 10

IL-10 Products

IL-10 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-10/IL10	Human	IL-10/IL10 Protein, Recombinant	10947-H07H

IL-10 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-10/IL10	Human	Human IL10 cDNA Clone / ORF Clone	HG10947-M
IL-10/IL10	Mouse	Mouse IL10 cDNA Clone / ORF Clone	MG50245-M
IL-10/IL10	Mouse	Mouse IL10 ORF Expression Clone, untagged	MG50245-M-N
IL-10/IL10	Canine	Canine IL10 cDNA Clone / ORF Clone	DG70022-G
IL-10/IL10	Rat	Rat IL-10/IL10 cDNA Clone / ORF Clone	RG80082-M

IL-10 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-10/IL10

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker / Monocyte Marker>>IL-10/IL10

Immunology>>Adaptive Immunity>>B Cell>>IL-10/IL10

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell / Regulatory T Cell>>IL-10/IL10

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IL-10/IL10

IL-10 Alternative Names

IL-10, IL10, RP11-262N9.1, CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF[Homo sapiens]

Il-10, Il10, AL513351.1, CSIF [Mus musculus]

IL-10 Background

IL-10 is a anti-inflammatory cytokine which belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.

IL-10 Related Studies

Ropelle ER. et al. (2010) IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS Biol. 8(8). pii:e1000465.
Arimoto T, et al. (2007) Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 28(6):894-906.
Han X, et al. (2010) Effect of cobalt protoporphyrin on hyperexpression of heme oxygenase-1 and secretion of IL-10 in rat bone marrow mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18(5):1297-301.
Cui QQ, et al. (2011) Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 77(7): 1436-41.